HCSGD entry for PSMB2

1. General information

Official gene symbolPSMB2
Entrez ID5690
Gene full nameproteasome (prosome, macropain) subunit, beta type, 2
Other gene symbolsHC7-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexISScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79228509560.50530344210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0274953982
GSE13712_SHEARDown-0.1908279551
GSE13712_STATICDown-0.0036415438
GSE19018Up0.2419442651
GSE19899_A1Down-0.1513836830
GSE19899_A2Up0.0785839137
PubMed_21979375_A1Down-0.2177990582
PubMed_21979375_A2Up0.1368110125
GSE35957Down-0.0409318691
GSE36640Down-0.0731737002
GSE54402Up0.1924122298
GSE9593Up0.1081750491
GSE43922Up0.0057239722
GSE24585Down-0.0939474491
GSE37065Up0.0923660119
GSE28863_A1Up0.1126390811
GSE28863_A2Down-0.0312175740
GSE28863_A3Down-0.2815667440
GSE28863_A4Down-0.1771955644
GSE48662Down-0.0611234537

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDB08515 -
CarfilzomibDB08889 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1226-3pMIMAT0005577MIRT036437CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037414CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051840CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.