HCSGD entry for PSMA2

1. General information

Official gene symbolPSMA2
Entrez ID5683
Gene full nameproteasome (prosome, macropain) subunit, alpha type, 2
Other gene symbolsHC3 MU PMSA2 PSC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0000932Cytoplasmic mRNA processing bodyISScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004175Endopeptidase activityIEAmolecular_function
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexIEA ISScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019773Proteasome core complex, alpha-subunit complexIEAcellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92510296340.10921392420.99999024730.6319715102

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3177331955
GSE13712_SHEARDown-0.2941526496
GSE13712_STATICDown-0.0929183627
GSE19018Down-0.4136148840
GSE19899_A1Up0.1547529675
GSE19899_A2Down-0.1653766221
PubMed_21979375_A1Up0.0994823858
PubMed_21979375_A2Down-0.0608250213
GSE35957Up0.0465346158
GSE36640Down-0.2330868346
GSE54402Up0.1737543108
GSE9593Down-0.2814112073
GSE43922Up0.0038791414
GSE24585Down-0.3074195294
GSE37065Up0.1738925304
GSE28863_A1Down-0.3012840969
GSE28863_A2Up0.0789315408
GSE28863_A3Down-0.5183619694
GSE28863_A4Down-0.1693811495
GSE48662Down-0.2611355613

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDB08515 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021801MicroarrayFunctional MTI (Weak)17612493
hsa-miR-29c-3pMIMAT0000681MIRT044238CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045072CLASHFunctional MTI (Weak)23622248
hsa-miR-191-5pMIMAT0000440MIRT045788CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048439CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048696CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052368CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.