HCSGD entry for EIF5A2
1. General information
| Official gene symbol | EIF5A2 |
|---|---|
| Entrez ID | 56648 |
| Gene full name | eukaryotic translation initiation factor 5A2 |
| Other gene symbols | EIF-5A2 eIF5AII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003746 | Translation elongation factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006452 | Translational frameshifting | IEA | biological_process |
| GO:0007283 | Spermatogenesis | NAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IGI | biological_process |
| GO:0008612 | Peptidyl-lysine modification to hypusine | IEA TAS | biological_process |
| GO:0010509 | Polyamine homeostasis | NAS | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0043022 | Ribosome binding | IEA | molecular_function |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045901 | Positive regulation of translational elongation | IEA | biological_process |
| GO:0045905 | Positive regulation of translational termination | IEA | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0120642263 | 0.3032972911 | 0.2745338807 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3841694648 |
| GSE13712_SHEAR | Down | -0.0691779150 |
| GSE13712_STATIC | Up | 0.6995473379 |
| GSE19018 | Down | -0.3709309612 |
| GSE19899_A1 | Up | 0.1618624722 |
| GSE19899_A2 | Up | 0.5406629669 |
| PubMed_21979375_A1 | Up | 1.9224923990 |
| PubMed_21979375_A2 | Up | 0.9063296505 |
| GSE35957 | Up | 1.7673641809 |
| GSE36640 | Up | 1.2796675203 |
| GSE54402 | Up | 0.0585357903 |
| GSE9593 | Up | 0.5213020079 |
| GSE43922 | Up | 0.1111788069 |
| GSE24585 | Down | -0.0009355471 |
| GSE37065 | Down | -0.1026379234 |
| GSE28863_A1 | Down | -0.6969356925 |
| GSE28863_A2 | Up | 0.4215089701 |
| GSE28863_A3 | Down | -1.0979004767 |
| GSE28863_A4 | Down | -0.3379236445 |
| GSE48662 | Down | -0.3126387102 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020474 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025671 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050216 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
