HCSGD entry for PSEN2

1. General information

Official gene symbolPSEN2
Entrez ID5664
Gene full namepresenilin 2 (Alzheimer disease 4)
Other gene symbolsAD3L AD4 CMD1V PS2 STM2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0000776KinetochoreIDAcellular_component
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001708Cell fate specificationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIEAbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIEAbiological_process
GO:0002286T cell activation involved in immune responseIEAbiological_process
GO:0002573Myeloid leukocyte differentiationIEAbiological_process
GO:0004175Endopeptidase activityIBA IEAmolecular_function
GO:0004190Aspartic-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005637Nuclear inner membraneIDAcellular_component
GO:0005743Mitochondrial inner membraneIBAcellular_component
GO:0005765Lysosomal membraneIBAcellular_component
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005938Cell cortexIBAcellular_component
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0006816Calcium ion transportIBA IEAbiological_process
GO:0007176Regulation of epidermal growth factor-activated receptor activityIEAbiological_process
GO:0007219Notch signaling pathwayIEA TASbiological_process
GO:0007220Notch receptor processingIBA TASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0009986Cell surfaceIBAcellular_component
GO:0015031Protein transportIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIBAcellular_component
GO:0016485Protein processingIDA IEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0030018Z discIBA IEAcellular_component
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030424AxonIBAcellular_component
GO:0030426Growth coneIBAcellular_component
GO:0030900Forebrain developmentIEAbiological_process
GO:0031293Membrane protein intracellular domain proteolysisTASbiological_process
GO:0031333Negative regulation of protein complex assemblyIEAbiological_process
GO:0031594Neuromuscular junctionIBAcellular_component
GO:0032091Negative regulation of protein bindingIEAbiological_process
GO:0032469Endoplasmic reticulum calcium ion homeostasisIEAbiological_process
GO:0035253Ciliary rootletIBAcellular_component
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0040011LocomotionIEAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0042987Amyloid precursor protein catabolic processIBA TASbiological_process
GO:0043025Neuronal cell bodyIBA IEAcellular_component
GO:0043065Positive regulation of apoptotic processIEA TASbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043198Dendritic shaftIBAcellular_component
GO:0043234Protein complexIDAcellular_component
GO:0044267Cellular protein metabolic processIEAbiological_process
GO:0045121Membrane raftIBAcellular_component
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048286Lung alveolus developmentIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIBAcellular_component
GO:0048538Thymus developmentIEAbiological_process
GO:0048854Brain morphogenesisIEAbiological_process
GO:0050435Beta-amyloid metabolic processIBA IEAbiological_process
GO:0050820Positive regulation of coagulationIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04960217700.87750273930.48843206141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2621348164
GSE13712_SHEARDown-0.3446303417
GSE13712_STATICUp0.0188307381
GSE19018Down-0.0667967759
GSE19899_A1Up0.0035512766
GSE19899_A2Up1.1422355248
PubMed_21979375_A1Up0.6345885660
PubMed_21979375_A2Up0.3428632223
GSE35957Up0.0892402146
GSE36640Up0.3722200266
GSE54402Down-0.2070896489
GSE9593Up0.5892160449
GSE43922Up0.4021995977
GSE24585Down-0.3375653319
GSE37065Up0.0815127357
GSE28863_A1Down-0.0442455040
GSE28863_A2Up0.5827473862
GSE28863_A3Down-0.2381019249
GSE28863_A4Up0.0323054631
GSE48662Up0.3991455186

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.