HCSGD entry for PSEN1

1. General information

Official gene symbolPSEN1
Entrez ID5663
Gene full namepresenilin 1
Other gene symbolsAD3 FAD PS-1 PS1 S182
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyIEAbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0000186Activation of MAPKK activityIEAbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0001568Blood vessel developmentIEAbiological_process
GO:0001708Cell fate specificationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001921Positive regulation of receptor recyclingIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIEAbiological_process
GO:0002286T cell activation involved in immune responseIEAbiological_process
GO:0002573Myeloid leukocyte differentiationIEAbiological_process
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004190Aspartic-type endopeptidase activityIEAmolecular_function
GO:0005262Calcium channel activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005640Nuclear outer membraneIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIBA IEAcellular_component
GO:0005765Lysosomal membraneIBA IEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005790Smooth endoplasmic reticulumIDAcellular_component
GO:0005791Rough endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005938Cell cortexIBAcellular_component
GO:0006486Protein glycosylationIEAbiological_process
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0006816Calcium ion transportIBAbiological_process
GO:0006839Mitochondrial transportIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIEAbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0007175Negative regulation of epidermal growth factor-activated receptor activityIEAbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0007220Notch receptor processingIBA IEA TASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009986Cell surfaceIBA IEAcellular_component
GO:0015031Protein transportIEAbiological_process
GO:0015813L-glutamate transportIEAbiological_process
GO:0015871Choline transportIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016080Synaptic vesicle targetingIEAbiological_process
GO:0016324Apical plasma membraneIBAcellular_component
GO:0016337Cell-cell adhesionIMPbiological_process
GO:0016485Protein processingIDAbiological_process
GO:0021795Cerebral cortex cell migrationIEAbiological_process
GO:0021870Cajal-Retzius cell differentiationIEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0030018Z discIBAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030424AxonIBA IEAcellular_component
GO:0030426Growth coneIBA IEAcellular_component
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0031594Neuromuscular junctionIBA IEAcellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0032469Endoplasmic reticulum calcium ion homeostasisIDA IGIbiological_process
GO:0034205Beta-amyloid formationIEAbiological_process
GO:0034220Ion transmembrane transportIMPbiological_process
GO:0035253Ciliary rootletIBA IEAcellular_component
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042325Regulation of phosphorylationIDAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0042987Amyloid precursor protein catabolic processIBA TASbiological_process
GO:0043025Neuronal cell bodyIBA IEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043198Dendritic shaftIBA IEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043393Regulation of protein bindingIEAbiological_process
GO:0043406Positive regulation of MAP kinase activityIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043589Skin morphogenesisIEAbiological_process
GO:0045121Membrane raftIBA IEAcellular_component
GO:0045296Cadherin bindingIBA IEAmolecular_function
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIBAcellular_component
GO:0048538Thymus developmentIEAbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0048854Brain morphogenesisIEAbiological_process
GO:0050435Beta-amyloid metabolic processIBAbiological_process
GO:0050673Epithelial cell proliferationIEAbiological_process
GO:0050771Negative regulation of axonogenesisIEAbiological_process
GO:0050820Positive regulation of coagulationIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0051444Negative regulation of ubiquitin-protein ligase activityIEAbiological_process
GO:0051563Smooth endoplasmic reticulum calcium ion homeostasisIBA IEAbiological_process
GO:0051604Protein maturationIEAbiological_process
GO:0051966Regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0055085Transmembrane transportIMPbiological_process
GO:0060075Regulation of resting membrane potentialIEAbiological_process
GO:0070588Calcium ion transmembrane transportIMPbiological_process
GO:0070765Gamma-secretase complexIDAcellular_component
GO:2000059Negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01837881160.99092686450.33178923181.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0680071275
GSE13712_SHEARUp0.1454032974
GSE13712_STATICUp0.1474395950
GSE19018Up0.2081588099
GSE19899_A1Up0.2976960663
GSE19899_A2Up0.4668843241
PubMed_21979375_A1Up0.0805841557
PubMed_21979375_A2Up0.5657079425
GSE35957Up0.2787089848
GSE36640Up0.4448591459
GSE54402Down-0.1057977179
GSE9593Up0.5899226318
GSE43922Up0.6292106012
GSE24585Up0.5779769801
GSE37065Up0.1586384297
GSE28863_A1Up0.2617907313
GSE28863_A2Up0.4143706081
GSE28863_A3Down-0.5203490150
GSE28863_A4Up0.0381530558
GSE48662Up0.0399882383

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-562MIMAT0003226MIRT005025Luciferase reporter assayNon-Functional MTI19789318
hsa-miR-155-5pMIMAT0000646MIRT020666ProteomicsFunctional MTI (Weak)18668040
hsa-miR-183-5pMIMAT0000261MIRT025010SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20578140These effects were due to a reduction of Notch1 cleavage by HBx through the suppression of presenilin1 (Psen1) transcription rather than inhibition of Notch1 transcription or its ligands' expression
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