HCSGD entry for PSD
1. General information
| Official gene symbol | PSD |
|---|---|
| Entrez ID | 5662 |
| Gene full name | pleckstrin and Sec7 domain containing |
| Other gene symbols | EFA6 EFA6A PSD1 TYL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0004871 | Signal transducer activity | NAS | molecular_function |
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005802 | Trans-Golgi network | IBA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016192 | Vesicle-mediated transport | IBA | biological_process |
| GO:0030054 | Cell junction | IBA | cellular_component |
| GO:0030182 | Neuron differentiation | IBA | biological_process |
| GO:0032012 | Regulation of ARF protein signal transduction | IEA | biological_process |
| GO:0043087 | Regulation of GTPase activity | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2540120398 | 0.8978221686 | 0.9440625388 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1014376317 |
| GSE13712_SHEAR | Up | 0.1101325919 |
| GSE13712_STATIC | Down | -0.0111002246 |
| GSE19018 | Down | -0.0006522532 |
| GSE19899_A1 | Down | -0.0388144655 |
| GSE19899_A2 | Up | 0.0022169364 |
| PubMed_21979375_A1 | Up | 0.1462652874 |
| PubMed_21979375_A2 | Up | 0.1396184822 |
| GSE35957 | Up | 0.2024911466 |
| GSE36640 | Up | 0.1530143525 |
| GSE54402 | Up | 0.0936617915 |
| GSE9593 | Down | -0.2474243793 |
| GSE43922 | Up | 0.0361418397 |
| GSE24585 | Up | 0.0479152909 |
| GSE37065 | Down | -0.0851009264 |
| GSE28863_A1 | Down | -0.1411966516 |
| GSE28863_A2 | Down | -0.1103985329 |
| GSE28863_A3 | Up | 0.2444527471 |
| GSE28863_A4 | Up | 0.0279376691 |
| GSE48662 | Up | 1.4869819287 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26336034 | We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene expression indicative of DNA damage responses (DDR), the senescence-associated secretory phenotype (SASP), and senescence indicator p16(INK4a) in older adult humans, who are at increased risk for cellular senescence |
| 26336034 | Community-dwelling older adults aged 61-86years (n=29; 48% male) underwent an experimental partial sleep deprivation (PSD) protocol over 4 nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (sleep restricted 3-7AM), and a subsequent full night of sleep |
| 26336034 | The senescence marker p16(INK4a) (CDKN2A) was increased 1day after PSD compared to baseline (p< |
| 26336034 | PSD enhanced the SASP and increased the accumulation of damage that initiates cell cycle arrest and promotes cellular senescence |
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