HCSGD entry for DIABLO
1. General information
| Official gene symbol | DIABLO |
|---|---|
| Entrez ID | 56616 |
| Gene full name | diablo, IAP-binding mitochondrial protein |
| Other gene symbols | DFNA64 SMAC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA TAS | biological_process |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | TAS | biological_process |
| GO:0008631 | Intrinsic apoptotic signaling pathway in response to oxidative stress | IEA | biological_process |
| GO:0008635 | Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | IEA | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | IEA ISS | cellular_component |
| GO:0035631 | CD40 receptor complex | IEA ISS | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0722276509 | 0.9709552373 | 0.5726216867 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5157354183 |
| GSE13712_SHEAR | Down | -0.1007368458 |
| GSE13712_STATIC | Up | 0.0929117785 |
| GSE19018 | Down | -0.1606972776 |
| GSE19899_A1 | Up | 0.0342050553 |
| GSE19899_A2 | Up | 0.1024344626 |
| PubMed_21979375_A1 | Up | 1.0995867883 |
| PubMed_21979375_A2 | Up | 0.4297974999 |
| GSE35957 | Up | 0.0759040900 |
| GSE36640 | Up | 0.2553055126 |
| GSE54402 | Up | 0.5180559277 |
| GSE9593 | Up | 0.1518022291 |
| GSE43922 | Up | 0.0602270257 |
| GSE24585 | Up | 0.1504670353 |
| GSE37065 | Up | 0.0335769214 |
| GSE28863_A1 | Down | -0.0338843499 |
| GSE28863_A2 | Down | -0.0061862392 |
| GSE28863_A3 | Down | -0.0158608003 |
| GSE28863_A4 | Down | -0.0033195661 |
| GSE48662 | Up | 0.3364088085 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT005907 | qRT-PCR | Functional MTI (Weak) | 21169019 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029197 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031535 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047377 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
