HCSGD entry for PRTN3
1. General information
| Official gene symbol | PRTN3 |
|---|---|
| Entrez ID | 5657 |
| Gene full name | proteinase 3 |
| Other gene symbols | ACPA AGP7 C-ANCA CANCA MBN MBT NP-4 NP4 P29 PR-3 PR3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030574 | Collagen catabolic process | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0050765 | Negative regulation of phagocytosis | IDA | biological_process |
| GO:0097029 | Mature dendritic cell differentiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7170362410 | 0.4631648874 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2279203186 |
| GSE13712_SHEAR | Up | 0.0104838143 |
| GSE13712_STATIC | Down | -0.1048040338 |
| GSE19018 | Up | 0.0075851120 |
| GSE19899_A1 | Up | 0.1406644371 |
| GSE19899_A2 | Down | -0.1054262986 |
| PubMed_21979375_A1 | Down | -0.3093739357 |
| PubMed_21979375_A2 | Down | -0.0667251445 |
| GSE35957 | Up | 0.0528795922 |
| GSE36640 | Down | -0.0336664964 |
| GSE54402 | Down | -0.0377112706 |
| GSE9593 | Up | 0.0844393657 |
| GSE43922 | Up | 0.1231611712 |
| GSE24585 | Up | 0.0800969955 |
| GSE37065 | Down | -0.1196656792 |
| GSE28863_A1 | Down | -0.1536360853 |
| GSE28863_A2 | Down | -0.2559974225 |
| GSE28863_A3 | Up | 0.5622005659 |
| GSE28863_A4 | Up | 0.0737352676 |
| GSE48662 | Down | -0.0832728250 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Elafin | DB05161 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
