HCSGD entry for RELN

1. General information

Official gene symbolRELN
Entrez ID5649
Gene full namereelin
Other gene symbolsLIS2 PRO1598 RL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000904Cell morphogenesis involved in differentiationISSbiological_process
GO:0001764Neuron migrationISSbiological_process
GO:0004712Protein serine/threonine/tyrosine kinase activityISSmolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0007417Central nervous system developmentISSbiological_process
GO:0007420Brain developmentISSbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0008236Serine-type peptidase activityIEAmolecular_function
GO:0008306Associative learningIEAbiological_process
GO:0010001Glial cell differentiationISSbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationISSbiological_process
GO:0021511Spinal cord patterningISSbiological_process
GO:0021517Ventral spinal cord developmentIEAbiological_process
GO:0021766Hippocampus developmentISSbiological_process
GO:0021800Cerebral cortex tangential migrationISSbiological_process
GO:0030425DendriteISScellular_component
GO:0032008Positive regulation of TOR signalingIEAbiological_process
GO:0032793Positive regulation of CREB transcription factor activityISSbiological_process
GO:0038026Reelin-mediated signaling pathwayISSbiological_process
GO:0045860Positive regulation of protein kinase activityISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048265Response to painISSbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0050795Regulation of behaviorISSbiological_process
GO:0050804Regulation of synaptic transmissionISSbiological_process
GO:0051057Positive regulation of small GTPase mediated signal transductionISSbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicISSbiological_process
GO:0061003Positive regulation of dendritic spine morphogenesisISSbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityISSbiological_process
GO:0070325Lipoprotein particle receptor bindingISSmolecular_function
GO:0070326Very-low-density lipoprotein particle receptor bindingISSmolecular_function
GO:0090129Positive regulation of synapse maturationISSbiological_process
GO:0097114N-methyl-D-aspartate receptor clusteringIEAbiological_process
GO:0097119Postsynaptic density protein 95 clusteringIEAbiological_process
GO:0097120Receptor localization to synapseIEAbiological_process
GO:0097477Lateral motor column neuron migrationIEAbiological_process
GO:1900273Positive regulation of long-term synaptic potentiationISSbiological_process
GO:1902078Positive regulation of lateral motor column neuron migrationIEAbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityISSbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:2000969Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17201865810.00036839030.81433508990.0355179487

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2306679459
GSE13712_SHEARDown-0.0379190398
GSE13712_STATICUp0.6566085283
GSE19018Up1.4035817248
GSE19899_A1Down-3.4004530502
GSE19899_A2Down-3.7721286884
PubMed_21979375_A1Down-3.7377490008
PubMed_21979375_A2Down-5.5151440515
GSE35957Up0.1834768708
GSE36640Up0.1783323831
GSE54402Down-3.8233786513
GSE9593Down-0.0559932996
GSE43922Down-4.0028892543
GSE24585Up0.2246257492
GSE37065Up0.0413570271
GSE28863_A1Down-0.5332664154
GSE28863_A2Up0.1844712347
GSE28863_A3Up0.4012581852
GSE28863_A4Up0.0267580270
GSE48662Down-0.0394947954

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT001071qRT-PCR//Western blot//Luciferase reporter assayFunctional MTI19713529
hsa-miR-138-5pMIMAT0000430MIRT007273Luciferase reporter assayFunctional MTI23438760
hsa-miR-10a-5pMIMAT0000253MIRT047548CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22708604This hypothesis emerged from our previous investigations of the aged hippocampus revealing layer-specific accumulations of Reelin, a glycoprotein with fundamental roles during brain development and adult synaptic plasticity
22708604We showed that Reelin deposits constitute a conserved neuropathological feature of aging, which is significantly accelerated in adult wild-type mice prenatally exposed to a viral-like infection
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