HCSGD entry for MASP1
1. General information
| Official gene symbol | MASP1 |
|---|---|
| Entrez ID | 5648 |
| Gene full name | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| Other gene symbols | 3MC1 CRARF CRARF1 MAP1 MASP MASP3 MAp44 PRSS5 RaRF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001867 | Complement activation, lectin pathway | IEA IMP TAS | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006956 | Complement activation | TAS | biological_process |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045916 | Negative regulation of complement activation | IDA | biological_process |
| GO:0048306 | Calcium-dependent protein binding | IEA IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3346517610 | 0.1584269367 | 0.9999902473 | 0.7692426674 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0878421076 |
| GSE13712_SHEAR | Up | 0.0868366668 |
| GSE13712_STATIC | Up | 0.0589183518 |
| GSE19018 | Up | 0.0915136356 |
| GSE19899_A1 | Down | -0.0278870716 |
| GSE19899_A2 | Down | -0.4907382340 |
| PubMed_21979375_A1 | Up | 0.0860188281 |
| PubMed_21979375_A2 | Down | -0.1366969593 |
| GSE35957 | Up | 0.2441300159 |
| GSE36640 | Up | 1.1629066399 |
| GSE54402 | Down | -0.4668842203 |
| GSE9593 | Up | 0.0657724325 |
| GSE43922 | Down | -0.4448122550 |
| GSE24585 | Down | -0.1985652887 |
| GSE37065 | Down | -0.0523236615 |
| GSE28863_A1 | Up | 0.4741174402 |
| GSE28863_A2 | Up | 0.0543404442 |
| GSE28863_A3 | Up | 0.3201489519 |
| GSE28863_A4 | Down | -0.5086686035 |
| GSE48662 | Up | 0.2756056939 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
