HCSGD entry for CCL28
1. General information
| Official gene symbol | CCL28 |
|---|---|
| Entrez ID | 56477 |
| Gene full name | chemokine (C-C motif) ligand 28 |
| Other gene symbols | CCK1 MEC SCYA28 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0008009 | Chemokine activity | IEA TAS | molecular_function |
| GO:0060326 | Cell chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3310455226 | 0.1854418943 | 0.9999902473 | 0.8347898238 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4525489647 |
| GSE13712_SHEAR | Down | -0.3413025696 |
| GSE13712_STATIC | Down | -0.1885928597 |
| GSE19018 | Up | 0.0853777984 |
| GSE19899_A1 | Down | -0.0396327536 |
| GSE19899_A2 | Up | 0.1072851599 |
| PubMed_21979375_A1 | Up | 0.0360851442 |
| PubMed_21979375_A2 | Up | 0.0643021727 |
| GSE35957 | Down | -0.7440437812 |
| GSE36640 | Down | -0.1914357489 |
| GSE54402 | Up | 0.5407968216 |
| GSE9593 | Up | 0.8810724710 |
| GSE43922 | Up | 0.0116557312 |
| GSE24585 | Down | -0.0002704058 |
| GSE37065 | Up | 0.2016223526 |
| GSE28863_A1 | Down | -0.7399826371 |
| GSE28863_A2 | Up | 0.6324391808 |
| GSE28863_A3 | Up | 0.0062334156 |
| GSE28863_A4 | Down | -0.0762066667 |
| GSE48662 | Up | 0.4657685289 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019466 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23262094 | To test our hypothesis, we chronically exposed adult wild-type (Wt) and DNA repair-deficient Ercc1(-/Delta) mice to the cancer therapeutic agent mechlorethamine (MEC) or ionization radiation (IR) to induce DNA damage and measured the impact on disc structure |
| 23262094 | Proteoglycan, a major structural matrix constituent of the disc, was reduced 3-5x in the discs of MEC- and IR-exposed animals compared to untreated controls |
| 23236989 | They contribute to mammary parenchyma development by stimulating mammary epithelial cell (MEC) proliferation |
| 23236989 | However several studies demonstrate that oestradiol negatively affects milk production during the declining phase of lactation, but the oestradiol effect on MEC in lactating mammary gland remains unclear |
| 23236989 | We demonstrated that oestradiol has a major effect on early apoptotic MECs and might accelerate MEC apoptosis by activation of caspases rather than by inducing apoptosis in active MECs |
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