HCSGD entry for PRSS3

1. General information

Official gene symbolPRSS3
Entrez ID5646
Gene full nameprotease, serine, 3
Other gene symbolsMTG PRSS4 T9 TRY3 TRY4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0006508ProteolysisIDA IEA NASbiological_process
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0007586DigestionTASbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0008236Serine-type peptidase activityIDAmolecular_function
GO:0009235Cobalamin metabolic processTASbiological_process
GO:0031638Zymogen activationIDAbiological_process
GO:0043542Endothelial cell migrationIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00002661750.98491599860.01490638301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.5777200568
GSE13712_SHEARUp1.1547390630
GSE13712_STATICUp1.4896261899
GSE19018Down-0.0611390636
GSE19899_A1Up4.0232186645
GSE19899_A2Up3.3796161929
PubMed_21979375_A1Up5.4022164753
PubMed_21979375_A2Up4.6093494611
GSE35957Up0.5690226229
GSE36640Up0.2448816134
GSE54402Up3.5630298090
GSE9593Up0.3555552470
GSE43922Up1.5536263697
GSE24585Up0.1592967465
GSE37065Up0.0608159452
GSE28863_A1Up0.0391225658
GSE28863_A2Up0.0283831344
GSE28863_A3Up0.1066868619
GSE28863_A4Down-0.1673525370
GSE48662Down-0.0616948211

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-AminiumDB02308 EXPT01310
4-Hydroxybutan-1-AminiumDB02541 EXPT00214
4-(Hydroxymethyl)BenzamidineDB02585 EXPT00206
BenzamidineDB03127 EXPT00669
[3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]GuanidineDB03129 EXPT02858
Guanidine-3-PropanolDB03637 EXPT02563
[4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]BenzamidineDB04109 EXPT02862
1,3,2-Dioxaborolan-2-OlDB04369 EXPT02853

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.