HCSGD entry for PRPS2
1. General information
| Official gene symbol | PRPS2 |
|---|---|
| Entrez ID | 5634 |
| Gene full name | phosphoribosyl pyrophosphate synthetase 2 |
| Other gene symbols | PRSII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0002189 | Ribose phosphate diphosphokinase complex | IEA | cellular_component |
| GO:0004749 | Ribose phosphate diphosphokinase activity | IEA ISS | molecular_function |
| GO:0005524 | ATP binding | ISS | molecular_function |
| GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process | IEA | biological_process |
| GO:0006139 | Nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006167 | AMP biosynthetic process | IEA | biological_process |
| GO:0009156 | Ribonucleoside monophosphate biosynthetic process | IEA | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | IEA | biological_process |
| GO:0016208 | AMP binding | IEA | molecular_function |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0019003 | GDP binding | IEA | molecular_function |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0043531 | ADP binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9696352038 | 0.0011767562 | 0.9999902473 | 0.0649337526 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0487605093 |
| GSE13712_SHEAR | Down | -0.8968345212 |
| GSE13712_STATIC | Down | -0.6041369451 |
| GSE19018 | Up | 0.3888952206 |
| GSE19899_A1 | Down | -0.6156200117 |
| GSE19899_A2 | Down | -2.2701449209 |
| PubMed_21979375_A1 | Down | -1.3496902437 |
| PubMed_21979375_A2 | Down | -2.6225356448 |
| GSE35957 | Up | 0.3623955680 |
| GSE36640 | Down | -1.5972151941 |
| GSE54402 | Down | -0.0954324445 |
| GSE9593 | Down | -0.6902825300 |
| GSE43922 | Down | -0.6202759699 |
| GSE24585 | Down | -1.1567319566 |
| GSE37065 | Down | -0.3075319471 |
| GSE28863_A1 | Up | 0.0680216597 |
| GSE28863_A2 | Up | 0.2343794247 |
| GSE28863_A3 | Down | -0.1064611963 |
| GSE28863_A4 | Up | 0.1084695901 |
| GSE48662 | Down | -0.4818474582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024389 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026537 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029585 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
