HCSGD entry for PRPS1
1. General information
| Official gene symbol | PRPS1 |
|---|---|
| Entrez ID | 5631 |
| Gene full name | phosphoribosyl pyrophosphate synthetase 1 |
| Other gene symbols | ARTS CMTX5 DFN2 DFNX1 PPRibP PRS-I PRSI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004749 | Ribose phosphate diphosphokinase activity | EXP IDA IEA IMP | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process | IEA TAS | biological_process |
| GO:0006144 | Purine nucleobase metabolic process | IMP | biological_process |
| GO:0006164 | Purine nucleotide biosynthetic process | IMP | biological_process |
| GO:0006221 | Pyrimidine nucleotide biosynthetic process | NAS | biological_process |
| GO:0007399 | Nervous system development | IMP | biological_process |
| GO:0009156 | Ribonucleoside monophosphate biosynthetic process | IEA | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0034418 | Urate biosynthetic process | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046101 | Hypoxanthine biosynthetic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1894566696 | 0.0117986627 | 0.8470215353 | 0.2145214483 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0784047565 |
| GSE13712_SHEAR | Down | -0.1247369940 |
| GSE13712_STATIC | Up | 0.0673311405 |
| GSE19018 | Up | 1.2726505831 |
| GSE19899_A1 | Down | -1.2374389095 |
| GSE19899_A2 | Down | -1.4319331762 |
| PubMed_21979375_A1 | Down | -2.0909540274 |
| PubMed_21979375_A2 | Down | -1.7563964920 |
| GSE35957 | Up | 1.0773520435 |
| GSE36640 | Up | 0.1789642590 |
| GSE54402 | Down | -0.2280456195 |
| GSE9593 | Down | -0.0550382543 |
| GSE43922 | Down | -1.5530716717 |
| GSE24585 | Down | -0.3556975925 |
| GSE37065 | Up | 0.0523700461 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.4058512410 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-376a-5p | MIMAT0003386 | MIRT001856 | Luciferase reporter assay | Non-Functional MTI | 17322061 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022908 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032397 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042233 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046478 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
