HCSGD entry for PROX1

1. General information

Official gene symbolPROX1
Entrez ID5629
Gene full nameprospero homeobox 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0001709Cell fate determinationIEAbiological_process
GO:0001822Kidney developmentIEPbiological_process
GO:0001889Liver developmentIEPbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0001946LymphangiogenesisIDAbiological_process
GO:0002088Lens development in camera-type eyeIEPbiological_process
GO:0002194Hepatocyte cell migrationIEAbiological_process
GO:0003677DNA bindingIEA IMPmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityICmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA ISSmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007420Brain developmentIEPbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIEA IMPbiological_process
GO:0010468Regulation of gene expressionIDAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0021516Dorsal spinal cord developmentISSbiological_process
GO:0021542Dentate gyrus developmentIEA ISSbiological_process
GO:0021707Cerebellar granule cell differentiationIEA ISSbiological_process
GO:0021915Neural tube developmentISSbiological_process
GO:0030240Skeletal muscle thin filament assemblyIEA ISSbiological_process
GO:0030324Lung developmentIEPbiological_process
GO:0030910Olfactory placode formationISSbiological_process
GO:0031016Pancreas developmentIEPbiological_process
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0043049Otic placode formationISSbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045737Positive regulation of cyclin-dependent protein kinase activityIDAbiological_process
GO:0045787Positive regulation of cell cycleIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046619Optic placode formation involved in camera-type eye formationIEA ISSbiological_process
GO:0048839Inner ear developmentIEAbiological_process
GO:0048845Venous blood vessel morphogenesisIEA ISSbiological_process
GO:0050692DBD domain bindingIPImolecular_function
GO:0050693LBD domain bindingIPImolecular_function
GO:0055005Ventricular cardiac myofibril assemblyIEA ISSbiological_process
GO:0055009Atrial cardiac muscle tissue morphogenesisIEA ISSbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIEA ISSbiological_process
GO:0060042Retina morphogenesis in camera-type eyeISSbiological_process
GO:0060059Embryonic retina morphogenesis in camera-type eyeIEA IEPbiological_process
GO:0060214Endocardium formationIEA ISSbiological_process
GO:0060298Positive regulation of sarcomere organizationIEA ISSbiological_process
GO:0060412Ventricular septum morphogenesisIEA ISSbiological_process
GO:0060414Aorta smooth muscle tissue morphogenesisIEA ISSbiological_process
GO:0060421Positive regulation of heart growthIEA ISSbiological_process
GO:0060836Lymphatic endothelial cell differentiationIDA IEAbiological_process
GO:0060849Regulation of transcription involved in lymphatic endothelial cell fate commitmentIMPbiological_process
GO:0070309Lens fiber cell morphogenesisIEA IEPbiological_process
GO:0070365Hepatocyte differentiationIEA IEPbiological_process
GO:0070858Negative regulation of bile acid biosynthetic processIMPbiological_process
GO:0072574Hepatocyte proliferationIEAbiological_process
GO:0097150Neuronal stem cell maintenanceIEA ISSbiological_process
GO:1901978Positive regulation of cell cycle checkpointIEAbiological_process
GO:2000179Positive regulation of neural precursor cell proliferationIEA ISSbiological_process
GO:2000979Positive regulation of forebrain neuron differentiationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59787234910.59580131450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0424801307
GSE13712_SHEARDown-0.8942219330
GSE13712_STATICDown-0.5162980438
GSE19018Up0.1364179765
GSE19899_A1Up0.0264785843
GSE19899_A2Down-0.0086349397
PubMed_21979375_A1Up0.2985385039
PubMed_21979375_A2Down-0.0481599904
GSE35957Up0.0388801439
GSE36640Down-0.0135276441
GSE54402Up0.0943848714
GSE9593Up0.0261818667
GSE43922Up0.0162784749
GSE24585Up0.6189736057
GSE37065Up0.2785631167
GSE28863_A1Down-0.1089131308
GSE28863_A2Up0.1244944325
GSE28863_A3Up0.0971137419
GSE28863_A4Down-0.0065660726
GSE48662Down-0.0069434696

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT003630Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20558617
hsa-miR-335-5pMIMAT0000765MIRT018128MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019318MicroarrayFunctional MTI (Weak)17612493
hsa-miR-877-5pMIMAT0004949MIRT037355CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.