HCSGD entry for PRLR

1. General information

Official gene symbolPRLR
Entrez ID5618
Gene full nameprolactin receptor
Other gene symbolshPRLrI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004896Cytokine receptor activityIEAmolecular_function
GO:0004925Prolactin receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006694Steroid biosynthetic processNASbiological_process
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityIDAbiological_process
GO:0007566Embryo implantationTASbiological_process
GO:0007595LactationNASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0017046Peptide hormone bindingIPImolecular_function
GO:0019221Cytokine-mediated signaling pathwayNAS TASbiological_process
GO:0031904Endosome lumenTAScellular_component
GO:0038161Prolactin signaling pathwayNAS TASbiological_process
GO:0042110T cell activationNASbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0042977Activation of JAK2 kinase activityNASbiological_process
GO:0042978Ornithine decarboxylase activator activityNASmolecular_function
GO:0043066Negative regulation of apoptotic processNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01074683330.97570153110.26311788691.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0207578653
GSE13712_SHEARDown-0.0245807169
GSE13712_STATICDown-0.0454136343
GSE19018Up0.0400982397
GSE19899_A1Up0.1234149258
GSE19899_A2Up0.6662804504
PubMed_21979375_A1Up0.7483319051
PubMed_21979375_A2Up0.3770904090
GSE35957Up0.0811729017
GSE36640Up1.0613406463
GSE54402Up0.6868532624
GSE9593Down-0.0288099862
GSE43922Up1.2865574123
GSE24585Up0.6279651039
GSE37065Up1.0658665699
GSE28863_A1Down-0.6877797066
GSE28863_A2Up0.6337180795
GSE28863_A3Up0.1199526969
GSE28863_A4Up0.0726891488
GSE48662Down-0.0218156440

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Somatropin recombinantDB00052 BTD00086 | BIOD00086

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT025183MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20032052The purpose of this study was to examine the impact of prolactin (PRL) on human sperm function, in light of a recent proteomic analysis indicating that these cells express the PRL receptor (PRLR)
20032052Immunocytochemical analyses confirmed the presence of PRLR in human spermatozoa and localized this receptor to the postacrosomal region of the sperm head as well as the neck, midpiece, and principal piece of the sperm tail
20032052Nested PCR analysis indicated that these cells possess four splice variants of the PRLR: the long form and three short isoforms, one of which is reported for the first time
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