HCSGD entry for PRKRIR
1. General information
| Official gene symbol | PRKRIR |
|---|---|
| Entrez ID | 5612 |
| Gene full name | protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) |
| Other gene symbols | DAP4 P52rIPK THAP0 THAP12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9794551575 | 0.0292746476 | 0.9999902473 | 0.3239605296 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0258595488 |
| GSE13712_SHEAR | Down | -0.1166279640 |
| GSE13712_STATIC | Down | -0.1614627530 |
| GSE19018 | Down | -0.2788721764 |
| GSE19899_A1 | Down | -0.2511524930 |
| GSE19899_A2 | Down | -0.2799199682 |
| PubMed_21979375_A1 | Down | -0.3155441248 |
| PubMed_21979375_A2 | Down | -0.0024837820 |
| GSE35957 | Down | -0.6709185808 |
| GSE36640 | Down | -0.7700412860 |
| GSE54402 | Up | 0.0495753865 |
| GSE9593 | Down | -0.3411560371 |
| GSE43922 | Down | -0.0200202672 |
| GSE24585 | Down | -0.3506421903 |
| GSE37065 | Down | -0.1517731870 |
| GSE28863_A1 | Up | 0.0159376339 |
| GSE28863_A2 | Up | 0.0974277529 |
| GSE28863_A3 | Down | -0.1765872547 |
| GSE28863_A4 | Up | 0.1686054188 |
| GSE48662 | Down | -0.7208877369 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025526 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025850 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027707 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030578 | Microarray | Functional MTI (Weak) | 19748357 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
