HCSGD entry for MAP2K3
1. General information
| Official gene symbol | MAP2K3 |
|---|---|
| Entrez ID | 5606 |
| Gene full name | mitogen-activated protein kinase kinase 3 |
| Other gene symbols | MAPKK3 MEK3 MKK3 PRKMK3 SAPKK-2 SAPKK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0004708 | MAP kinase kinase activity | IBA IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IEA IPI | molecular_function |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042035 | Regulation of cytokine biosynthetic process | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0060048 | Cardiac muscle contraction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8976557388 | 0.9093753391 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0007062324 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-214-3p | MIMAT0000271 | MIRT005426 | GFP reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;qRT-PCR;Microarray;Other | Functional MTI | 19859982 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022960 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028553 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21137025 | Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer |
| 21137025 | Cell and molecular biology and immunohistochemistry were used to validate involvement of mitogen-activated protein kinase kinase 3 (MAP2K3) in the immortalization-senescence transition |
| 21137025 | We observed that MAP2K3 was downregulated in immortal human breast epithelial cells and that upregulation of MAP2K3 expression promoted cell senescence |
| 21137025 | Decreased expression of MAP2K3 was observed in human breast infiltrating ductal carcinomas, as compared to non-cancerous human breast tissues |
| 21137025 | CONCLUSION AND CLINICAL RELEVANCE: we described a proteome profile of the immortalization-to-senescence transition for human breast epithelial cells, and identified MAP2K3 as a protein that promotes senescence in these cells |
| 17762881 | Thus, the balance between the two stress-signaling pathways, MKK7-JNK and MKK3/6-p38-MAPK, determines cell fate and links environmental and developmental stress to cell cycle arrest, senescence, oncogenic transformation, and adult tissue regeneration |
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