HCSGD entry for MAPK4
1. General information
| Official gene symbol | MAPK4 |
|---|---|
| Entrez ID | 5596 |
| Gene full name | mitogen-activated protein kinase 4 |
| Other gene symbols | ERK-4 ERK3 Erk4 MAPK 4 PRKM4 p63MAPK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IEA ISS | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA ISS | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8209915429 | 0.5592114623 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0259562976 |
| GSE13712_SHEAR | Up | 0.0451533388 |
| GSE13712_STATIC | Down | -0.1273636687 |
| GSE19018 | Up | 0.1256015163 |
| GSE19899_A1 | Up | 0.0715792594 |
| GSE19899_A2 | Down | -0.0480591403 |
| PubMed_21979375_A1 | Up | 0.0657337947 |
| PubMed_21979375_A2 | Down | -0.1774887929 |
| GSE35957 | Up | 0.1090840033 |
| GSE36640 | Up | 0.0338923807 |
| GSE54402 | Up | 0.0493765109 |
| GSE9593 | Down | -0.0010959990 |
| GSE43922 | Down | -0.0749554111 |
| GSE24585 | Down | -0.5435542964 |
| GSE37065 | Down | -0.0981278169 |
| GSE28863_A1 | Down | -0.0673614870 |
| GSE28863_A2 | Down | -0.0305340891 |
| GSE28863_A3 | Up | 0.2553035039 |
| GSE28863_A4 | Up | 0.1005561846 |
| GSE48662 | Up | 0.2148358403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016876 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
