HCSGD entry for PRKG2
1. General information
| Official gene symbol | PRKG2 |
|---|---|
| Entrez ID | 5593 |
| Gene full name | protein kinase, cGMP-dependent, type II |
| Other gene symbols | PRKGR2 cGKII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004692 | CGMP-dependent protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0030553 | CGMP binding | IEA | molecular_function |
| GO:0032922 | Circadian regulation of gene expression | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0038826868 | 0.8903279929 | 0.1672605565 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1645564413 |
| GSE13712_SHEAR | Up | 0.0243894106 |
| GSE13712_STATIC | Down | -0.1412359193 |
| GSE19018 | Up | 0.0291580164 |
| GSE19899_A1 | Down | -0.1409167186 |
| GSE19899_A2 | Up | 1.2193164761 |
| PubMed_21979375_A1 | Up | 2.7563839741 |
| PubMed_21979375_A2 | Up | 1.4233964279 |
| GSE35957 | Up | 0.7825173805 |
| GSE36640 | Up | 0.1726370850 |
| GSE54402 | Up | 0.3568688786 |
| GSE9593 | Up | 0.1796019814 |
| GSE43922 | Up | 2.2731530591 |
| GSE24585 | Up | 0.0894693442 |
| GSE37065 | Up | 0.0113423834 |
| GSE28863_A1 | Up | 0.4784424310 |
| GSE28863_A2 | Up | 1.3740297746 |
| GSE28863_A3 | Down | -0.3915628861 |
| GSE28863_A4 | Down | -0.5516965971 |
| GSE48662 | Down | -0.0593175932 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018075 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023857 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
