HCSGD entry for KMT2E
1. General information
| Official gene symbol | KMT2E |
|---|---|
| Entrez ID | 55904 |
| Gene full name | lysine (K)-specific methyltransferase 2E |
| Other gene symbols | HDCMC04P MLL5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002446 | Neutrophil mediated immunity | IEA ISS | biological_process |
| GO:0003713 | Transcription coactivator activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006306 | DNA methylation | IEA ISS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030218 | Erythrocyte differentiation | IEA ISS | biological_process |
| GO:0030854 | Positive regulation of granulocyte differentiation | IMP | biological_process |
| GO:0042119 | Neutrophil activation | IEA ISS | biological_process |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0048384 | Retinoic acid receptor signaling pathway | IMP | biological_process |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
| GO:0071300 | Cellular response to retinoic acid | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6839621101 | 0.0303851867 | 0.9999902473 | 0.3292158848 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2763146137 |
| GSE13712_SHEAR | Down | -0.1694818576 |
| GSE13712_STATIC | Down | -0.0551094630 |
| GSE19018 | Up | 0.2517933922 |
| GSE19899_A1 | Down | -0.8740410005 |
| GSE19899_A2 | Down | -0.8544331098 |
| PubMed_21979375_A1 | Down | -1.2306279982 |
| PubMed_21979375_A2 | Down | -1.2240391881 |
| GSE35957 | Down | -0.2475401622 |
| GSE36640 | Down | -0.2385495740 |
| GSE54402 | Down | -0.0587994383 |
| GSE9593 | Up | 0.0238664604 |
| GSE43922 | Down | -0.6765202332 |
| GSE24585 | Up | 0.4537732434 |
| GSE37065 | Up | 0.3538535832 |
| GSE28863_A1 | Up | 0.3136019316 |
| GSE28863_A2 | Up | 0.7158908229 |
| GSE28863_A3 | Down | -0.1408595603 |
| GSE28863_A4 | Down | -0.3061453435 |
| GSE48662 | Up | 0.0917966684 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017069 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036034 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
