HCSGD entry for HDAC8

1. General information

Official gene symbolHDAC8
Entrez ID55869
Gene full namehistone deacetylase 8
Other gene symbolsCDLS5 HD8 HDACL1 MRXS6 RPD3 WTS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexTAScellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000228Nuclear chromosomeTAScellular_component
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004407Histone deacetylase activityIEA TASmolecular_function
GO:0005634NucleusTAScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006333Chromatin assembly or disassemblyTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007062Sister chromatid cohesionIMPbiological_process
GO:0008134Transcription factor bindingTASmolecular_function
GO:0016568Chromatin modificationTASbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)IEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)IEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)IEAmolecular_function
GO:0071922Regulation of cohesin localization to chromatinIMPbiological_process
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)IEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84958289580.14266055240.99999024730.7275660531

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0828943001
GSE13712_SHEARDown-0.4641935809
GSE13712_STATICDown-0.0607014017
GSE19018Down-0.1435562029
GSE19899_A1Down-0.0873710182
GSE19899_A2Down-0.4845805091
PubMed_21979375_A1Down-0.7126501131
PubMed_21979375_A2Down-0.8699520540
GSE35957Up0.0517583371
GSE36640Down-0.1102155273
GSE54402Up0.1734415339
GSE9593Down-0.3648101729
GSE43922Down-0.0798041327
GSE24585Up0.1003752286
GSE37065Up0.1092417745
GSE28863_A1Up0.4007348883
GSE28863_A2Up0.0657967572
GSE28863_A3Down-0.1875250643
GSE28863_A4Up0.1476170563
GSE48662Down-0.1177350382

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

VorinostatDB02546 EXPT02902
4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)AminoheptanamideDB02565 EXPT00611
N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)BenzamideDB02917 EXPT02343
7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-HeptadienamideDB04297 EXPT03123
PanobinostatDB06603 -
(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamideDB07350 -
5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDEDB07586 -
7-AMINO-4-METHYL-CHROMEN-2-ONEDB08168 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-449aMIMAT0001541MIRT003761Western blotNon-Functional MTI19252524
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.