HCSGD entry for PKN2
1. General information
| Official gene symbol | PKN2 |
|---|---|
| Entrez ID | 5586 |
| Gene full name | protein kinase N2 |
| Other gene symbols | PAK2 PRK2 PRKCL2 PRO2042 Pak-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004697 | Protein kinase C activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0010631 | Epithelial cell migration | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0042826 | Histone deacetylase binding | IDA | molecular_function |
| GO:0043296 | Apical junction complex | IDA | cellular_component |
| GO:0043297 | Apical junction assembly | IMP | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:2000145 | Regulation of cell motility | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6749884009 | 0.1737319783 | 0.9999902473 | 0.8073445268 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1354984482 |
| GSE13712_SHEAR | Up | 0.2853634962 |
| GSE13712_STATIC | Up | 0.1504337577 |
| GSE19018 | Up | 0.3711601399 |
| GSE19899_A1 | Down | -0.0792513534 |
| GSE19899_A2 | Down | -0.2771228598 |
| PubMed_21979375_A1 | Down | -0.5026592107 |
| PubMed_21979375_A2 | Down | -0.3000537962 |
| GSE35957 | Up | 0.0069903685 |
| GSE36640 | Down | -0.0495089991 |
| GSE54402 | Down | -0.2022068709 |
| GSE9593 | Up | 0.0043670978 |
| GSE43922 | Down | -0.3403900114 |
| GSE24585 | Up | 0.4999660988 |
| GSE37065 | Up | 0.1281985665 |
| GSE28863_A1 | Down | -0.0447487981 |
| GSE28863_A2 | Up | 0.4670543812 |
| GSE28863_A3 | Down | -0.5588658054 |
| GSE28863_A4 | Down | -0.3578125299 |
| GSE48662 | Up | 0.0415621711 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001524 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001524 | Reporter assay;Other | Functional MTI | 20584899 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15236317 | The candidate genes PRKCL2 and GTF2B, within SRO2, and TGFBR3, CDC7, and EVI5, in a broad region encompassing SRO3, were screened in 1p22-linked melanoma kindreds, but no coding mutations were detected |
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