HCSGD entry for PAG1
1. General information
| Official gene symbol | PAG1 |
|---|---|
| Entrez ID | 55824 |
| Gene full name | phosphoprotein associated with glycosphingolipid microdomains 1 |
| Other gene symbols | CBP PAG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009967 | Positive regulation of signal transduction | NAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0042169 | SH2 domain binding | IDA | molecular_function |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0050863 | Regulation of T cell activation | IDA | biological_process |
| GO:0050868 | Negative regulation of T cell activation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0024307701 | 0.9149720185 | 0.1330151767 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5639449464 |
| GSE13712_SHEAR | Down | -0.0617704613 |
| GSE13712_STATIC | Down | -0.0044680690 |
| GSE19018 | Down | -0.5387799093 |
| GSE19899_A1 | Up | 0.7154086941 |
| GSE19899_A2 | Up | 0.6517116595 |
| PubMed_21979375_A1 | Up | 1.2368085289 |
| PubMed_21979375_A2 | Up | 2.3955479858 |
| GSE35957 | Down | -0.1727111146 |
| GSE36640 | Up | 0.4184212037 |
| GSE54402 | Up | 0.4433252045 |
| GSE9593 | Up | 2.5159101280 |
| GSE43922 | Up | 1.0572438696 |
| GSE24585 | Down | -0.4975076326 |
| GSE37065 | Up | 0.1182305237 |
| GSE28863_A1 | Down | -0.2623956545 |
| GSE28863_A2 | Up | 1.2491140623 |
| GSE28863_A3 | Down | -0.0151106777 |
| GSE28863_A4 | Up | 0.0536564095 |
| GSE48662 | Up | 0.1095312727 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027134 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030922 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031726 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
