HCSGD entry for PRKCG

1. General information

Official gene symbolPRKCG
Entrez ID5582
Gene full nameprotein kinase C, gamma
Other gene symbolsPKC-gamma PKCC PKCG SCA14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004697Protein kinase C activityIEA TASmolecular_function
GO:0004698Calcium-dependent protein kinase C activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEA ISS TAScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionIEA TASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0007635Chemosensory behaviorIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0016310PhosphorylationIDAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030425DendriteIEA ISScellular_component
GO:0031397Negative regulation of protein ubiquitinationIDAbiological_process
GO:0032425Positive regulation of mismatch repairIDAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042177Negative regulation of protein catabolic processIDAbiological_process
GO:0043278Response to morphineIEA ISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048265Response to painIEA ISSbiological_process
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
GO:0060384InnervationIEAbiological_process
GO:0097060Synaptic membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43763582690.75689071840.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0653834801
GSE13712_SHEARUp0.0556962090
GSE13712_STATICDown-0.1912599487
GSE19018Up0.0025867790
GSE19899_A1Up0.0249005168
GSE19899_A2Up0.1670439951
PubMed_21979375_A1Down-0.1366042851
PubMed_21979375_A2Down-0.2411494978
GSE35957Down-0.0872043237
GSE36640Up0.0310317685
GSE54402Down-0.0794498740
GSE9593Up0.1257230612
GSE43922Up0.2175920250
GSE24585Up0.3958485259
GSE37065Down-0.2250140130
GSE28863_A1Down-0.1897133428
GSE28863_A2Up0.0005493838
GSE28863_A3Up0.4945423394
GSE28863_A4Up0.2017899900
GSE48662Up0.1791525160

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017708MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26703243Overexpression of the PKC isoforms: PKCalpha, PKCbeta, and PKCzeta, but not PKCgamma, stimulated CK2 activity in the cells
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