HCSGD entry for AXL

1. General information

Official gene symbolAXL
Entrez ID558
Gene full nameAXL receptor tyrosine kinase
Other gene symbolsJTK11 UFO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0001786Phosphatidylserine bindingIDAmolecular_function
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIDAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006909PhagocytosisIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007167Enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0021885Forebrain cell migrationIEAbiological_process
GO:0030168Platelet activationIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032036Myosin heavy chain bindingIEAmolecular_function
GO:0032689Negative regulation of interferon-gamma productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIDAbiological_process
GO:0032940Secretion by cellIEAbiological_process
GO:0034101Erythrocyte homeostasisIEAbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0035457Cellular response to interferon-alphaIDAbiological_process
GO:0042698Ovulation cycleIEAbiological_process
GO:0043277Apoptotic cell clearanceIEAbiological_process
GO:0043491Protein kinase B signalingIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0045087Innate immune responseIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048469Cell maturationIEPbiological_process
GO:0051250Negative regulation of lymphocyte activationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0060068Vagina developmentIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0097028Dendritic cell differentiationIEPbiological_process
GO:2000669Negative regulation of dendritic cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81251723340.00216305610.99999024730.0897617323

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5376066567
GSE13712_SHEARUp0.8873690017
GSE13712_STATICUp0.4398300468
GSE19018Up0.4802660938
GSE19899_A1Down-1.6579971847
GSE19899_A2Down-1.8492454030
PubMed_21979375_A1Down-1.7160896180
PubMed_21979375_A2Down-1.6795773040
GSE35957Down-0.0434389190
GSE36640Down-1.2056324320
GSE54402Down-1.3875732649
GSE9593Down-0.4771683478
GSE43922Down-1.0946735563
GSE24585Up0.1054598142
GSE37065Down-0.2652023498
GSE28863_A1Up0.3896900972
GSE28863_A2Up0.1952249603
GSE28863_A3Down-0.1096971653
GSE28863_A4Up0.0404371158
GSE48662Down-0.4687585308

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002758Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-1MIMAT0000416MIRT002758pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT006664Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21814748
hsa-miR-34a-5pMIMAT0000255MIRT006664Reporter assay;ProteomicsFunctional MTI21566225
hsa-miR-375MIMAT0000728MIRT019798MicroarrayFunctional MTI (Weak)20215506
hsa-miR-155-5pMIMAT0000646MIRT020726ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
hsa-miR-34a-5pMIMAT00002551hsa-miR-34a{Western blot}{overexpression by miRNA precursor transfection}21317930
hsa-miR-199b-5pMIMAT0000263NAhsa-miR-199b-5p21317930
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27206970The effects on VSMCs senescence and collagen synthesis were mediated by restoration of angiotensin II-induced downregulation of Gas6 and Axl expression and a subsequent reduction of Akt and FoxO1a phosphorylation
27206970The effects of testosterone were reversed by a Gas6 blocker, Axl-Fc, and a specific inhibitor of Axl, R428
25766527Previous studies have confirmed that Gas6 is involved in certain pathophysiological processes of the cardiovascular system through binding to its receptor, Axl
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