HCSGD entry for CHFR
1. General information
| Official gene symbol | CHFR |
|---|---|
| Entrez ID | 55743 |
| Gene full name | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase |
| Other gene symbols | RNF116 RNF196 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IDA | molecular_function |
| GO:0000209 | Protein polyubiquitination | IDA IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | IMP TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0019941 | Modification-dependent protein catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8702254246 | 0.1220694427 | 0.9999902473 | 0.6700708655 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1016731398 |
| GSE13712_SHEAR | Up | 0.2709311354 |
| GSE13712_STATIC | Up | 0.0741067388 |
| GSE19018 | Down | -0.4093275383 |
| GSE19899_A1 | Down | -0.4726347751 |
| GSE19899_A2 | Down | -0.4146341856 |
| PubMed_21979375_A1 | Down | -0.8188205934 |
| PubMed_21979375_A2 | Down | -0.2835574299 |
| GSE35957 | Up | 0.0236921734 |
| GSE36640 | Up | 0.2310733077 |
| GSE54402 | Up | 0.2732097346 |
| GSE9593 | Up | 0.0642935020 |
| GSE43922 | Up | 0.0494895935 |
| GSE24585 | Up | 0.3753074290 |
| GSE37065 | Down | -0.1901395087 |
| GSE28863_A1 | Up | 0.0017176704 |
| GSE28863_A2 | Down | -0.1290844775 |
| GSE28863_A3 | Down | -0.2243155763 |
| GSE28863_A4 | Down | -0.1299867934 |
| GSE48662 | Down | -0.1965654589 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT030587 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047652 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | NA | hsa-miR-26b | 20831567 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
