HCSGD entry for PRKAR1A

1. General information

Official gene symbolPRKAR1A
Entrez ID5573
Gene full nameprotein kinase, cAMP-dependent, regulatory, type I, alpha
Other gene symbolsACRDYS1 ADOHR CAR CNC CNC1 PKR1 PPNAD1 PRKAR1 TSE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001707Mesoderm formationIEAbiological_process
GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006469Negative regulation of protein kinase activityIEAbiological_process
GO:0006833Water transportTASbiological_process
GO:0007143Female meiosisIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDA IEAmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0031588AMP-activated protein kinase complexIDAcellular_component
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035556Intracellular signal transductionTASbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045214Sarcomere organizationIEAbiological_process
GO:0045835Negative regulation of meiosisIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12933660200.94794953840.73051057711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0803001861
GSE13712_SHEARUp0.4213093631
GSE13712_STATICUp0.2105679970
GSE19018Up0.0662685100
GSE19899_A1Up0.2098908753
GSE19899_A2Down-0.0078709271
PubMed_21979375_A1Down-0.2845898086
PubMed_21979375_A2Up0.0486670626
GSE35957Up0.0039679720
GSE36640Up0.3016158290
GSE54402Up0.0675127862
GSE9593Down-0.1841690130
GSE43922Up0.1357261643
GSE24585Up0.7390439418
GSE37065Up0.0157611140
GSE28863_A1Up0.1183390371
GSE28863_A2Up0.0401634729
GSE28863_A3Down-0.3206618462
GSE28863_A4Up0.0499894082
GSE48662Up0.1755006080

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL52529CHEMBL49285P10644
CHEMBL294166CHEMBL49285P10644
CHEMBL299987CHEMBL49285P10644
CHEMBL298159CHEMBL49285P10644
CHEMBL298872CHEMBL49285P10644
CHEMBL52869CHEMBL49285P10644
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  • Drugs

Name

Drug

Accession number

Sp-Adenosine-3',5'-Cyclic-MonophosphorothioateDB01790 EXPT02808 | EXPT02940
Cyclic Guanosine MonophosphateDB02315 EXPT02518 | DB04536
Cyclic Adenosine MonophosphateDB02527 EXPT00959
GEM-231DB05798 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020712Reporter assay;OtherFunctional MTI20584899
hsa-miR-215-5pMIMAT0000272MIRT024953MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026380MicroarrayFunctional MTI (Weak)19074876
hsa-miR-16-5pMIMAT0000069MIRT031552ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1296-5pMIMAT0005794MIRT036121CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042851CLASHFunctional MTI (Weak)23622248
hsa-miR-204-5pMIMAT0000265MIRT047010CLASHFunctional MTI (Weak)23622248
hsa-miR-96-5pMIMAT0000095MIRT048733CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050285CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16288019We have shown previously that patients with the autosomal dominant tumor predisposition Carney complex carry inactivating mutations in the PRKAR1A gene, which encodes the type 1A regulatory subunit of protein kinase A (PKA), the cyclic AMP-dependent protein kinase
16288019To determine the mechanism by which dysregulation of PKA causes tumor formation, we generated in vitro primary mouse cells lacking the Prkar1a protein
16288019At the molecular level, knockout of Prkar1a leads to up-regulation of D-type cyclins, and this increase occurs independently of other pathways known to increase cyclin D levels
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