HCSGD entry for POLR3B

1. General information

Official gene symbolPOLR3B
Entrez ID55703
Gene full namepolymerase (RNA) III (DNA directed) polypeptide B
Other gene symbolsC128 HLD8 RPC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001056RNA polymerase III activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005666DNA-directed RNA polymerase III complexIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006383Transcription from RNA polymerase III promoterTASbiological_process
GO:0006385Transcription elongation from RNA polymerase III promoterTASbiological_process
GO:0006386Termination of RNA polymerase III transcriptionTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032549Ribonucleoside bindingIEAmolecular_function
GO:0032728Positive regulation of interferon-beta productionIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045089Positive regulation of innate immune responseIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051607Defense response to virusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92018249310.17256229630.99999024730.8042068520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2668165861
GSE13712_SHEARDown-0.0237477780
GSE13712_STATICDown-0.1390796218
GSE19018Down-0.0947374810
GSE19899_A1Down-0.0467249627
GSE19899_A2Up0.0360223108
PubMed_21979375_A1Down-0.3286675209
PubMed_21979375_A2Up0.2170016890
GSE35957Up0.1917683048
GSE36640Up0.1804832246
GSE54402Down-0.3031933244
GSE9593Down-0.3680380573
GSE43922Down-0.0179383687
GSE24585Down-0.1548114710
GSE37065Down-0.2003398316
GSE28863_A1Down-0.2200871657
GSE28863_A2Down-0.0870014191
GSE28863_A3Down-0.4479062449
GSE28863_A4Down-0.0374686837
GSE48662Up0.1104652274

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030785MicroarrayFunctional MTI (Weak)18591254
hsa-let-7b-5pMIMAT0000063MIRT032193ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.