HCSGD entry for LIMS2
1. General information
| Official gene symbol | LIMS2 |
|---|---|
| Entrez ID | 55679 |
| Gene full name | LIM and senescent cell antigen-like domains 2 |
| Other gene symbols | PINCH-2 PINCH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0045216 | Cell-cell junction organization | IEA | biological_process |
| GO:2001046 | Positive regulation of integrin-mediated signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8462068652 | 0.0107441017 | 0.9999902473 | 0.2053219884 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.3048556672 |
| GSE13712_SHEAR | Down | -0.4947936547 |
| GSE13712_STATIC | Down | -0.8895676051 |
| GSE19018 | Down | -0.2973067197 |
| GSE19899_A1 | Down | -0.8510631723 |
| GSE19899_A2 | Down | -0.8322833013 |
| PubMed_21979375_A1 | Down | -0.5126973651 |
| PubMed_21979375_A2 | Down | -0.7269348607 |
| GSE35957 | Up | 0.8733074089 |
| GSE36640 | Up | 0.5321351118 |
| GSE54402 | Down | -0.4544038056 |
| GSE9593 | Down | -0.5313606143 |
| GSE43922 | Down | -0.0722558444 |
| GSE24585 | Up | 0.0557446107 |
| GSE37065 | Down | -0.2288565635 |
| GSE28863_A1 | Up | 0.0390891316 |
| GSE28863_A2 | Down | -0.0402987380 |
| GSE28863_A3 | Up | 0.2925458258 |
| GSE28863_A4 | Up | 0.1254927729 |
| GSE48662 | Up | 0.1580197344 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25346044 | PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity |
| 25346044 | Among these CNVs, LIM and senescent cell antigen-like domain 2 (PINCH-2) showed copy number amplification and upregulation of mRNA in the nonrelapsed group compared to the systemic relapse group |
| 25346044 | PINCH-2 expression in colon cancer cells was lower than that in normal epithelial colon cells at both the protein and mRNA levels |
| 25346044 | Suppression of PINCH-2 resulted in decreased formation of the PINCH-2-IPP (PINCH-2, integrin-linked kinase and alpha-parvin) complex and reciprocally increased formation of the PINCH-1-IPP complex |
| 25346044 | Although PINCH-2 expression of survival pathway-related proteins (Akt and phospho-Akt) did not change upon suppression of PINCH-2 expression, cell migration-related proteins [matrix-metalloproteinase (MMP)-9 and -11] were upregulated through autocrine and paracrine activation |
| 25346044 | Thus, PINCH-2 participates in decreased systemic recurrence by competitively regulating IPP complex formation with PINCH-1, thereby suppressing autocrine and paracrine effects on motility in colon cancer |
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