HCSGD entry for PRKAB1
1. General information
| Official gene symbol | PRKAB1 |
|---|---|
| Entrez ID | 5564 |
| Gene full name | protein kinase, AMP-activated, beta 1 non-catalytic subunit |
| Other gene symbols | AMPK HAMPKb |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010628 | Positive regulation of gene expression | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0031588 | AMP-activated protein kinase complex | IEA | cellular_component |
| GO:0050790 | Regulation of catalytic activity | IEA | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1417070590 | 0.5690900802 | 0.7561061220 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3493423465 |
| GSE13712_SHEAR | Up | 0.4269747658 |
| GSE13712_STATIC | Up | 0.1479930342 |
| GSE19018 | Down | -0.2492342836 |
| GSE19899_A1 | Down | -0.1398491410 |
| GSE19899_A2 | Down | -0.4370188232 |
| PubMed_21979375_A1 | Up | 0.7173278829 |
| PubMed_21979375_A2 | Down | -0.6771635747 |
| GSE35957 | Down | -0.0062210757 |
| GSE36640 | Up | 0.2467216126 |
| GSE54402 | Down | -0.3288078855 |
| GSE9593 | Up | 0.6959692413 |
| GSE43922 | Up | 0.0018438635 |
| GSE24585 | Up | 0.2520109189 |
| GSE37065 | Up | 0.0201349639 |
| GSE28863_A1 | Up | 0.3044055946 |
| GSE28863_A2 | Up | 0.5763139757 |
| GSE28863_A3 | Down | -0.1689165020 |
| GSE28863_A4 | Up | 0.1351162215 |
| GSE48662 | Down | -0.1823869249 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Metformin | DB00331 | APRD01099 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT004527 | Luciferase reporter assay | Functional MTI | 16459310 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16673436 | We have screened proteins involved in both cellular senescence and reactive oxygen species induced condition using 2-D gel analysis and found that ubiquitin carboxyl terminal hydrolase L1, peroxyredoxin 2, peroxyredoxin 4, fatty acid binding proteins (FABPs), and 5'-AMP-activated protein kinase beta-1 subunit were candidate aging-related proteins |
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