HCSGD entry for AMBRA1
1. General information
| Official gene symbol | AMBRA1 |
|---|---|
| Entrez ID | 55626 |
| Gene full name | autophagy/beclin-1 regulator 1 |
| Other gene symbols | DCAF3 WDR94 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005776 | Autophagic vacuole | IEA | cellular_component |
| GO:0005930 | Axoneme | ISS | cellular_component |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0021915 | Neural tube development | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1845252080 | 0.9794595152 | 0.8394206706 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0299066844 |
| GSE13712_SHEAR | Up | 0.0921677420 |
| GSE13712_STATIC | Up | 0.3129990271 |
| GSE19018 | Up | 0.0749459326 |
| GSE19899_A1 | Up | 0.0750406588 |
| GSE19899_A2 | Up | 0.2459895092 |
| PubMed_21979375_A1 | Up | 0.0228845014 |
| PubMed_21979375_A2 | Up | 0.2337580411 |
| GSE35957 | Up | 0.1008734474 |
| GSE36640 | Down | -0.1078407573 |
| GSE54402 | Up | 0.2163311282 |
| GSE9593 | Down | -0.0461997463 |
| GSE43922 | Up | 0.1532013092 |
| GSE24585 | Up | 0.1865713896 |
| GSE37065 | Up | 0.2312851923 |
| GSE28863_A1 | Up | 0.3226910474 |
| GSE28863_A2 | Up | 0.1064699793 |
| GSE28863_A3 | Down | -0.0557977639 |
| GSE28863_A4 | Up | 0.0025423587 |
| GSE48662 | Up | 0.0754331473 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-339-5p | MIMAT0000764 | MIRT042802 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043533 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045188 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
