HCSGD entry for OTUB1
1. General information
| Official gene symbol | OTUB1 |
|---|---|
| Entrez ID | 55611 |
| Gene full name | OTU domain, ubiquitin aldehyde binding 1 |
| Other gene symbols | OTB1 OTU1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002376 | Immune system process | IEA | biological_process |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008242 | Omega peptidase activity | IEA | molecular_function |
| GO:0019538 | Protein metabolic process | IEA | biological_process |
| GO:0019784 | NEDD8-specific protease activity | IDA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0071108 | Protein K48-linked deubiquitination | IDA | biological_process |
| GO:1901315 | Negative regulation of histone H2A K63-linked ubiquitination | IDA | biological_process |
| GO:2000780 | Negative regulation of double-strand break repair | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8102029520 | 0.9043875119 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0646369156 |
| GSE28863_A2 | Down | -0.2763237191 |
| GSE28863_A3 | Down | -0.0530515198 |
| GSE28863_A4 | Up | 0.1373172736 |
| GSE48662 | Up | 0.2492419088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-28-5p | MIMAT0000085 | MIRT006414 | Luciferase reporter assay | Functional MTI | 20445018 |
| hsa-miR-708-3p | MIMAT0004927 | MIRT006415 | Luciferase reporter assay | Functional MTI | 20445018 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038748 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051514 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051986 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
