HCSGD entry for RBM38

1. General information

Official gene symbolRBM38
Entrez ID55544
Gene full nameRNA binding motif protein 38
Other gene symbolsHSRNASEB RNPC1 SEB4B SEB4D dJ800J21.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003729MRNA bindingIDA IEAmolecular_function
GO:0003730MRNA 3'-UTR bindingIDAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0006397MRNA processingIEAbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0010830Regulation of myotube differentiationIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0043484Regulation of RNA splicingIDAbiological_process
GO:00709353'-UTR-mediated mRNA stabilizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66541216520.23763473650.99999024730.9384521980

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1347264078
GSE13712_SHEARDown-0.7447630782
GSE13712_STATICDown-0.0099097098
GSE19018Down-0.3074824340
GSE19899_A1Down-0.0565012156
GSE19899_A2Up0.4407202602
PubMed_21979375_A1Down-0.2817202628
PubMed_21979375_A2Up0.4510080563
GSE35957Up0.1852146122
GSE36640Down-0.4711660223
GSE54402Up0.2376344876
GSE9593Down-0.2901305214
GSE43922Up0.0539862168
GSE24585Up0.1094371737
GSE37065Down-0.2033261360
GSE28863_A1Down-0.1361603062
GSE28863_A2Down-0.1444158569
GSE28863_A3Up0.2072876657
GSE28863_A4Up0.0695392252
GSE48662Down-0.0012759933

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044628CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22508983Here, we found that p73 mRNA stability is regulated by RNPC1, an RNA binding protein and a target of the p53 family
22508983We also showed that a CU-rich element in the 3' untranslated region of p73 is recognized by and responsive to RNPC1
22508983To explore the physiological significance of RNPC1-regulated p73 expression, we showed that the loss of RNPC1 in p53-null mouse embryonic fibroblasts leads to reduced expression of p73, along with decreased expression of p21, p130, and gamma-H2A
22508983Furthermore, we observed that knockdown of TAp73 or p21, another target of RNPC1, attenuates the inhibitory effect of RNPC1 on cell proliferation and premature senescence, whereas combined knockdown of TAp73 and p21 completely abolishes it
22508983Due to the fact that RNPC1 is a target of p73, the mutual regulation between p73 and RNPC1 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional p53
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