HCSGD entry for SRGN

1. General information

Official gene symbolSRGN
Entrez ID5552
Gene full nameserglycin
Other gene symbolsPPG PRG PRG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0007596Blood coagulationTASbiological_process
GO:0008626Granzyme-mediated apoptotic signaling pathwayIDAbiological_process
GO:0016485Protein processingISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030502Negative regulation of bone mineralizationIDAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031214Biomineral tissue developmentIEAbiological_process
GO:0033364Mast cell secretory granule organizationISSbiological_process
GO:0033371T cell secretory granule organizationISSbiological_process
GO:0033373Maintenance of protease location in mast cell secretory granuleISSbiological_process
GO:0033382Maintenance of granzyme B location in T cell secretory granuleISSbiological_process
GO:0042588Zymogen granuleIEAcellular_component
GO:0042629Mast cell granuleISScellular_component
GO:0050710Negative regulation of cytokine secretionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25532732040.00673162110.94707869220.1645429499

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1456088885
GSE13712_SHEARUp0.5475605421
GSE13712_STATICUp0.3340193294
GSE19018Up0.4066740253
GSE19899_A1Down-1.6376402359
GSE19899_A2Down-0.6145186546
PubMed_21979375_A1Down-1.4716146165
PubMed_21979375_A2Down-2.8490291519
GSE35957Up0.0838538822
GSE36640Down-1.2708844265
GSE54402Down-0.3448465807
GSE9593Down-0.0335845045
GSE43922Down-0.6825105980
GSE24585Up0.1713590929
GSE37065Up0.2665677959
GSE28863_A1Down-1.0321359003
GSE28863_A2Down-0.1892085794
GSE28863_A3Up0.7161320389
GSE28863_A4Up0.5960988288
GSE48662Down-0.4906336059

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028982MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.