HCSGD entry for PRF1

1. General information

Official gene symbolPRF1
Entrez ID5551
Gene full nameperforin 1 (pore forming protein)
Other gene symbolsFLH2 HPLH2 P1 PFN1 PFP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002357Defense response to tumor cellISSbiological_process
GO:0002418Immune response to tumor cellISSbiological_process
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006810TransportIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0019835CytolysisISSbiological_process
GO:0022829Wide pore channel activityIDAmolecular_function
GO:0031904Endosome lumenIEAcellular_component
GO:0044194Cytolytic granuleISScellular_component
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051607Defense response to virusISSbiological_process
GO:0055085Transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70879424410.87445338320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1008200167
GSE13712_SHEARDown-0.1153192978
GSE13712_STATICUp0.0000800949
GSE19018Up0.0889359375
GSE19899_A1Up0.0568872496
GSE19899_A2Up0.1787193125
PubMed_21979375_A1Up0.0107379380
PubMed_21979375_A2Up0.1327346683
GSE35957Up0.1145046150
GSE36640Down-0.1211352492
GSE54402Up0.0483765102
GSE9593Down-0.1877790498
GSE43922Up0.0242729936
GSE24585Up0.0623287634
GSE37065Up0.0522151643
GSE28863_A1Up0.0881930457
GSE28863_A2Up0.0022054342
GSE28863_A3Up0.1944576034
GSE28863_A4Down-0.0038744135
GSE48662Up0.0706830446

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24033117Plantar fat pad (PFP) is a tissue structure that absorbs the initial impact of walking and running and ultimately bears body weight at standing
24033117This study was designed to quantify the histomorphological changes of the PFP in aged rats
24033117The most medial PFP was dissected from the hind feet of young rats (4 months old, n = 6) and aged rats (24 months old, n = 6)
24033117Histological structure and cellular senescence of PFP were analyzed stereologically and histomorphometrically
24033117Immunohistochemistry of matrix metalloproteinase 9 (MMP9) was also performed on PFP tissue sections
24033117Compared with young rats, the thickness of epidermis, dermis and septa of the PFP were significantly reduced in the aged rats
24033117The total volume of adipose tissue in the PFP of aged rats was only about 65% of that in the young rats
24033117The microvascular density and the number of fat pad units (FPU), a cluster of adipocytes enclosed by elastin septa, in the PFP were unchanged in the aged rats
24033117The shift of the types of adipocyte clusters in the aged PFP was accompanied by degradation of elastin fibers and increased expression of MMP9
24033117In conclusion, the PFP, particularly the elastic septa, degenerates significantly in aged rats and this may contribute to the pathology of PFP-related diseases
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