HCSGD entry for PREP
1. General information
| Official gene symbol | PREP |
|---|---|
| Entrez ID | 5550 |
| Gene full name | prolyl endopeptidase |
| Other gene symbols | PE PEP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0070008 | Serine-type exopeptidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2811888454 | 0.3764225257 | 0.9786026180 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2217941040 |
| GSE13712_SHEAR | Down | -0.0111373987 |
| GSE13712_STATIC | Up | 0.2352209554 |
| GSE19018 | Up | 0.0382410040 |
| GSE19899_A1 | Down | -0.0073961141 |
| GSE19899_A2 | Up | 0.5328114549 |
| PubMed_21979375_A1 | Up | 0.3758176912 |
| PubMed_21979375_A2 | Up | 0.6022200960 |
| GSE35957 | Down | -0.4106005549 |
| GSE36640 | Down | -0.5285600536 |
| GSE54402 | Up | 0.5112526308 |
| GSE9593 | Down | -0.2340158997 |
| GSE43922 | Up | 0.2505610021 |
| GSE24585 | Down | -0.5391355311 |
| GSE37065 | Up | 0.0006705372 |
| GSE28863_A1 | Up | 0.2681937387 |
| GSE28863_A2 | Up | 0.4246002394 |
| GSE28863_A3 | Up | 0.0105365481 |
| GSE28863_A4 | Down | -0.3048995446 |
| GSE48662 | Down | -0.1717353799 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-Hydroxy-1-Thio-Glycerol | DB01684 | EXPT02896 |
| Double Oxidized Cysteine | DB01769 | EXPT01040 |
| S-Oxy Cysteine | DB03382 | EXPT01041 |
| Z-Pro-Prolinal | DB03535 | EXPT03293 |
| Monothioglycerol | DB03864 | EXPT02897 |
| (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one | DB07148 | - |
| 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one | DB08738 | - |
| 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione | DB08739 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035971 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
