HCSGD entry for PARL
1. General information
| Official gene symbol | PARL |
|---|---|
| Entrez ID | 55486 |
| Gene full name | presenilin associated, rhomboid-like |
| Other gene symbols | PSARL PSARL1 PSENIP2 RHBDS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0090201 | Negative regulation of release of cytochrome c from mitochondria | IEA | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0426540215 | 0.9358345162 | 0.4612557518 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3231717417 |
| GSE13712_SHEAR | Up | 0.0967842529 |
| GSE13712_STATIC | Up | 0.2495657580 |
| GSE19018 | Down | -0.3111469813 |
| GSE19899_A1 | Up | 0.3850581211 |
| GSE19899_A2 | Up | 0.5869827195 |
| PubMed_21979375_A1 | Up | 1.6519283642 |
| PubMed_21979375_A2 | Up | 0.4197239059 |
| GSE35957 | Up | 0.0841085012 |
| GSE36640 | Up | 0.4130284281 |
| GSE54402 | Up | 0.5646870123 |
| GSE9593 | Down | -0.0606453354 |
| GSE43922 | Up | 0.2858254088 |
| GSE24585 | Down | -0.0455457375 |
| GSE37065 | Down | -0.0820782892 |
| GSE28863_A1 | Down | -0.0279608075 |
| GSE28863_A2 | Up | 0.0604920389 |
| GSE28863_A3 | Down | -0.2706788996 |
| GSE28863_A4 | Down | -0.1458486702 |
| GSE48662 | Down | -0.0361164849 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035965 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047451 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047666 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050358 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
