HCSGD entry for PIDD
1. General information
| Official gene symbol | PIDD |
|---|---|
| Entrez ID | 55367 |
| Gene full name | p53-induced death domain protein |
| Other gene symbols | LRDD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005123 | Death receptor binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IMP | cellular_component |
| GO:0005737 | Cytoplasm | IMP | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA IEA | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | IMP | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0530147829 | 0.7867771589 | 0.5035734753 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4356361206 |
| GSE13712_SHEAR | Up | 0.1349786185 |
| GSE13712_STATIC | Up | 0.0401974480 |
| GSE19018 | Up | 0.0998931923 |
| GSE19899_A1 | Up | 0.2543144162 |
| GSE19899_A2 | Up | 0.6010557271 |
| PubMed_21979375_A1 | Up | 0.0939323751 |
| PubMed_21979375_A2 | Up | 0.9725031429 |
| GSE35957 | Down | -0.4277022652 |
| GSE36640 | Up | 0.2608135986 |
| GSE54402 | Down | -0.4064149983 |
| GSE9593 | Down | -0.2240462333 |
| GSE43922 | Up | 0.5292612247 |
| GSE24585 | Up | 0.1812179131 |
| GSE37065 | Up | 0.0709073248 |
| GSE28863_A1 | Down | -0.2035472314 |
| GSE28863_A2 | Down | -0.2967254068 |
| GSE28863_A3 | Up | 0.5262704104 |
| GSE28863_A4 | Down | -0.0475420417 |
| GSE48662 | Up | 0.1276011052 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028912 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25536232 | Furthermore, real-time polymerase chain reaction (PCR) showed that pretreatment with PS1145 inhibited the increase of mRNA expressions of interleukin-6 (IL-6) and p53-induced death domain (PIDD) protein, which have been show to play crucial roles in both senescence and apoptosis (P < 0 |
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