HCSGD entry for PPP3R1
1. General information
| Official gene symbol | PPP3R1 |
|---|---|
| Entrez ID | 5534 |
| Gene full name | protein phosphatase 3, regulatory subunit B, alpha |
| Other gene symbols | CALNB1 CNB CNB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004723 | Calcium-dependent protein serine/threonine phosphatase activity | NAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | NAS | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005955 | Calcineurin complex | NAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0016311 | Dephosphorylation | NAS | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0679495688 | 0.5408052392 | 0.5605946445 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2407853319 |
| GSE13712_SHEAR | Up | 0.5117033683 |
| GSE13712_STATIC | Up | 0.1025172411 |
| GSE19018 | Down | -0.6983263453 |
| GSE19899_A1 | Up | 0.3017602439 |
| GSE19899_A2 | Up | 0.3062077568 |
| PubMed_21979375_A1 | Up | 1.0629867734 |
| PubMed_21979375_A2 | Up | 0.1734565331 |
| GSE35957 | Up | 0.0695976667 |
| GSE36640 | Down | -0.1659034092 |
| GSE54402 | Up | 0.3509364693 |
| GSE9593 | Down | -0.3239495484 |
| GSE43922 | Up | 0.2878396760 |
| GSE24585 | Down | -0.5634591656 |
| GSE37065 | Down | -0.0468748913 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.4743789715 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005180 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025005 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025426 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029303 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030457 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-532-3p | MIMAT0004780 | MIRT037914 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
