HCSGD entry for PPP2R5C
1. General information
| Official gene symbol | PPP2R5C |
|---|---|
| Entrez ID | 5527 |
| Gene full name | protein phosphatase 2, regulatory subunit B', gamma |
| Other gene symbols | B56G PR61G |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000159 | Protein phosphatase type 2A complex | IDA IEA NAS | cellular_component |
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | IDA | biological_process |
| GO:0007165 | Signal transduction | IEA NAS | biological_process |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0008601 | Protein phosphatase type 2A regulator activity | IDA IEA NAS | molecular_function |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0016485 | Protein processing | IDA | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IMP | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0050790 | Regulation of catalytic activity | IDA NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9687437825 | 0.0925718058 | 0.9999902473 | 0.5797246015 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1310553188 |
| GSE13712_SHEAR | Down | -0.1800772619 |
| GSE13712_STATIC | Down | -0.0155802328 |
| GSE19018 | Up | 0.2261329865 |
| GSE19899_A1 | Down | -0.1265061324 |
| GSE19899_A2 | Down | -0.1886697833 |
| PubMed_21979375_A1 | Down | -0.4509490572 |
| PubMed_21979375_A2 | Down | -0.5814991739 |
| GSE35957 | Down | -0.2199127567 |
| GSE36640 | Down | -0.2877268698 |
| GSE54402 | Down | -0.1853825918 |
| GSE9593 | Down | -0.0918514403 |
| GSE43922 | Down | -0.6244441635 |
| GSE24585 | Down | -0.0080881091 |
| GSE37065 | Up | 0.1052272887 |
| GSE28863_A1 | Up | 0.1200724234 |
| GSE28863_A2 | Up | 0.0989182984 |
| GSE28863_A3 | Down | -0.1289567962 |
| GSE28863_A4 | Up | 0.0736895530 |
| GSE48662 | Down | -0.3298425357 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | DB02506 | EXPT00428 |
| (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid | DB06905 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001428 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028561 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT038933 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
