HCSGD entry for PPP2R1A

1. General information

Official gene symbolPPP2R1A
Entrez ID5518
Gene full nameprotein phosphatase 2, regulatory subunit A, alpha
Other gene symbolsPP2A-Aalpha PP2AAALPHA PR65A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000159Protein phosphatase type 2A complexIDA IEA TAScellular_component
GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTASbiological_process
GO:0000188Inactivation of MAPK activityNASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionIDAcellular_component
GO:0003823Antigen bindingIPImolecular_function
GO:0004722Protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusNAScellular_component
GO:0005739MitochondrionNAScellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006275Regulation of DNA replicationNASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006461Protein complex assemblyTASbiological_process
GO:0006470Protein dephosphorylationTASbiological_process
GO:0006672Ceramide metabolic processNASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007059Chromosome segregationIDAbiological_process
GO:0007084Mitotic nuclear envelope reassemblyTASbiological_process
GO:0008380RNA splicingNASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008601Protein phosphatase type 2A regulator activityTASmolecular_function
GO:0010033Response to organic substanceNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0015630Microtubule cytoskeletonNAScellular_component
GO:0016020MembraneNAScellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019932Second-messenger-mediated signalingNASbiological_process
GO:0030111Regulation of Wnt signaling pathwayNASbiological_process
GO:0030155Regulation of cell adhesionNASbiological_process
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0040008Regulation of growthNASbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinNASbiological_process
GO:0045595Regulation of cell differentiationNASbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0070262Peptidyl-serine dephosphorylationIEAbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10353552300.40909285740.66906698581.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3571396061
GSE13712_SHEARDown-0.4447062115
GSE13712_STATICDown-0.1738545877
GSE19018Up0.4704191597
GSE19899_A1Down-0.3978844180
GSE19899_A2Up0.7084309790
PubMed_21979375_A1Up0.7265032419
PubMed_21979375_A2Up0.5824573638
GSE35957Up0.2545490358
GSE36640Up0.2628493440
GSE54402Up0.2265945665
GSE9593Up0.3729674057
GSE43922Down-0.0020747637
GSE24585Down-0.2205926186
GSE37065Down-0.1174093382
GSE28863_A1Up0.2471702646
GSE28863_A2Down-0.0085294901
GSE28863_A3Down-0.7627148924
GSE28863_A4Down-0.0006501764
GSE48662Down-0.1440599275

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDB02506 EXPT00428
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDB06905 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031709ProteomicsFunctional MTI (Weak)18668040
hsa-miR-941MIMAT0004984MIRT036561CLASHFunctional MTI (Weak)23622248
hsa-miR-505-5pMIMAT0004776MIRT037954CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046765CLASHFunctional MTI (Weak)23622248
hsa-miR-106a-5pMIMAT0000103MIRT048343CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049765CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050575CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050961CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051517CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22961627In a search for proteins interacting with human telomerase reverse transcriptase hTERT by the yeast two-hybrid screen using hTERT T-motif as bait, we identified PP2A scaffolding subunit PR65 alpha isoform as an hTERT interacting partner
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