HCSGD entry for PPP2CA

1. General information

Official gene symbolPPP2CA
Entrez ID5515
Gene full nameprotein phosphatase 2, catalytic subunit, alpha isozyme
Other gene symbolsPP2Ac PP2CA PP2Calpha RP-C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000159Protein phosphatase type 2A complexIDA IEA TAScellular_component
GO:0000184Nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTASbiological_process
GO:0000188Inactivation of MAPK activityNASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionIEAcellular_component
GO:0000922Spindle poleIEAcellular_component
GO:0004721Phosphoprotein phosphatase activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusNAScellular_component
GO:0005739MitochondrionNAScellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006275Regulation of DNA replicationNASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006470Protein dephosphorylationIEA TASbiological_process
GO:0006672Ceramide metabolic processNASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007084Mitotic nuclear envelope reassemblyTASbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0007498Mesoderm developmentIEAbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008380RNA splicingNASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010033Response to organic substanceNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010469Regulation of receptor activityIEAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0015630Microtubule cytoskeletonNAScellular_component
GO:0016020MembraneNAScellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019932Second-messenger-mediated signalingNASbiological_process
GO:0030111Regulation of Wnt signaling pathwayNASbiological_process
GO:0030155Regulation of cell adhesionNASbiological_process
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0031952Regulation of protein autophosphorylationIEAbiological_process
GO:0040008Regulation of growthNASbiological_process
GO:0042176Regulation of protein catabolic processIEAbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinNASbiological_process
GO:0045595Regulation of cell differentiationNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0070208Protein heterotrimerizationIEAbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99049770150.02925167360.99999024730.3239605296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2489869476
GSE13712_SHEARUp0.0454904890
GSE13712_STATICUp0.1442399839
GSE19018Down-0.5808183944
GSE19899_A1Down-0.0648848531
GSE19899_A2Down-0.7947868122
PubMed_21979375_A1Down-0.3081701118
PubMed_21979375_A2Down-0.7090058077
GSE35957Down-0.0550475577
GSE36640Down-0.5608617429
GSE54402Down-0.1653050716
GSE9593Down-0.2368939116
GSE43922Down-0.0120356531
GSE24585Up0.2158786128
GSE37065Up0.0677141770
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.5199323357

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL346552CHEMBL47038P67775
CHEMBL158524CHEMBL47038P67775
CHEMBL1237212CHEMBL47038P67775
CHEMBL175576CHEMBL47038P67775
CHEMBL6951CHEMBL47038P67775
CHEMBL367750CHEMBL47038P67775
CHEMBL48449CHEMBL47038P67775
CHEMBL175630CHEMBL47038P67775
CHEMBL425851CHEMBL47038P67775
CHEMBL177853CHEMBL47038P67775
CHEMBL175996CHEMBL47038P67775
CHEMBL99039CHEMBL47034P67775
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  • Drugs

Name

Drug

Accession number

Vitamin EDB00163 NUTR00061 | EXPT03227
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDB02506 EXPT00428
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDB06905 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-340-3pMIMAT0000750MIRT043848CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048079CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b21935352
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24295239RESULTS: We have reported that Fas-associated protein with death domain (FADD) phosphorylation abolishes the recruitment of phosphatase type 2A C subunit (PP2Ac) to protein kinase C (PKC)betaII, which specifically regulates mitochondrial ROS generation by p66shc
21420382In addition, HDAC1 overexpression led to senescence through both an accumulation of hypophosphorylated active retinoblastoma protein (pRb) and an increase in the protein level of protein phosphatase 2A catalytic subunit (PP2Ac)
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