HCSGD entry for HERC6
1. General information
| Official gene symbol | HERC6 |
|---|---|
| Entrez ID | 55008 |
| Gene full name | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IBA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0060328559 | 0.7245737320 | 0.2049247742 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2760627302 |
| GSE13712_SHEAR | Up | 1.5205855073 |
| GSE13712_STATIC | Up | 0.8784014251 |
| GSE19018 | Up | 0.0203673772 |
| GSE19899_A1 | Up | 0.0281425720 |
| GSE19899_A2 | Up | 0.0445168720 |
| PubMed_21979375_A1 | Down | -0.0062169219 |
| PubMed_21979375_A2 | Up | 0.2080585144 |
| GSE35957 | Down | -0.9068447378 |
| GSE36640 | Up | 1.2714677232 |
| GSE54402 | Down | -0.2597906161 |
| GSE9593 | Up | 0.2292940213 |
| GSE43922 | Down | -0.0410449572 |
| GSE24585 | Up | 0.8761645767 |
| GSE37065 | Up | 1.7233025377 |
| GSE28863_A1 | Down | -0.3937453332 |
| GSE28863_A2 | Up | 2.6270143677 |
| GSE28863_A3 | Down | -0.2289152217 |
| GSE28863_A4 | Down | -0.1113444944 |
| GSE48662 | Up | 0.0381470896 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000858 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000859 | Microarray | Functional MTI (Weak) | 18362358 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
