HCSGD entry for PPP1CB
1. General information
| Official gene symbol | PPP1CB |
|---|---|
| Entrez ID | 5500 |
| Gene full name | protein phosphatase 1, catalytic subunit, beta isozyme |
| Other gene symbols | PP-1B PP1B PP1beta PPP1CD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004722 | Protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005977 | Glycogen metabolic process | IEA | biological_process |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0017018 | Myosin phosphatase activity | ISS | molecular_function |
| GO:0019433 | Triglyceride catabolic process | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030155 | Regulation of cell adhesion | IDA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050115 | Myosin-light-chain-phosphatase activity | IDA | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
| GO:0072357 | PTW/PP1 phosphatase complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9955479465 | 0.0343508529 | 0.9999902473 | 0.3504452713 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4141346258 |
| GSE13712_SHEAR | Up | 0.0187438060 |
| GSE13712_STATIC | Up | 0.0436398206 |
| GSE19018 | Up | 0.1820648788 |
| GSE19899_A1 | Down | -0.2398904047 |
| GSE19899_A2 | Down | -0.5361373326 |
| PubMed_21979375_A1 | Down | -0.4003615793 |
| PubMed_21979375_A2 | Down | -0.6362401168 |
| GSE35957 | Down | -0.3766483973 |
| GSE36640 | Down | -0.3273902092 |
| GSE54402 | Down | -0.2294285524 |
| GSE9593 | Down | -0.2764510242 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1110682556 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024868 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026142 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031341 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040166 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040560 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041041 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046264 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046516 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
