HCSGD entry for PPP1CA
1. General information
| Official gene symbol | PPP1CA |
|---|---|
| Entrez ID | 5499 |
| Gene full name | protein phosphatase 1, catalytic subunit, alpha isozyme |
| Other gene symbols | PP-1A PP1A PP1alpha PPP1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000164 | Protein phosphatase type 1 complex | IEA | cellular_component |
| GO:0004721 | Phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005977 | Glycogen metabolic process | IEA | biological_process |
| GO:0005979 | Regulation of glycogen biosynthetic process | IEA | biological_process |
| GO:0005981 | Regulation of glycogen catabolic process | IEA | biological_process |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0019433 | Triglyceride catabolic process | TAS | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0042587 | Glycogen granule | IEA | cellular_component |
| GO:0043021 | Ribonucleoprotein complex binding | IEA | molecular_function |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0043204 | Perikaryon | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
| GO:0072357 | PTW/PP1 phosphatase complex | IDA | cellular_component |
| GO:2001241 | Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4866085483 | 0.1764151780 | 0.9999902473 | 0.8129899510 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0797995646 |
| GSE13712_SHEAR | Up | 0.1971599718 |
| GSE13712_STATIC | Down | -0.0681624929 |
| GSE19018 | Down | -0.2324255689 |
| GSE19899_A1 | Down | -0.1353191413 |
| GSE19899_A2 | Up | 0.2102826030 |
| PubMed_21979375_A1 | Up | 1.4095375501 |
| PubMed_21979375_A2 | Down | -0.1513466090 |
| GSE35957 | Down | -0.6202492315 |
| GSE36640 | Down | -0.8574650749 |
| GSE54402 | Up | 0.7083701629 |
| GSE9593 | Down | -0.4011740336 |
| GSE43922 | Up | 0.1676990949 |
| GSE24585 | Up | 0.1512692656 |
| GSE37065 | Down | -0.2324590508 |
| GSE28863_A1 | Down | -0.0464482425 |
| GSE28863_A2 | Down | -0.2969918172 |
| GSE28863_A3 | Down | -0.2234525474 |
| GSE28863_A4 | Up | 0.1682156146 |
| GSE48662 | Down | -0.1389839085 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | DB02506 | EXPT00428 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-5p | MIMAT0003886 | MIRT016090 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024705 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026892 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037406 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051034 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26677227 | We show that Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation |
| 18800172 | This study tested whether PPP1CA (the catalytic subunit of PP1alpha), recently identified as contributing to Ras-induced senescence, might be this second signal |
| 18800172 | PPP1CA is induced by Ras; its inactivation inhibits Ras-induced senescence, presumably by inhibiting pRb dephosphorylation |
| 18800172 | Finally, PPP1CA seems to strongly co-localize with pRb only during senescence |
| 18800172 | PPP1CA is induced by Ras; its inactivation inhibits Ras-induced senescence, presumably by inhibiting pRb dephosphorylation |
| 18800172 | Finally, PPP1CA seems to strongly co-localize with pRb only during senescence, suggesting that PP1alpha activation during senescence may be the second signal contributing to the irreversibility of the senescent phenotype |
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