HCSGD entry for SPDL1
1. General information
| Official gene symbol | SPDL1 |
|---|---|
| Entrez ID | 54908 |
| Gene full name | spindle apparatus coiled-coil protein 1 |
| Other gene symbols | CCDC99 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000132 | Establishment of mitotic spindle orientation | IMP | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0000940 | Condensed chromosome outer kinetochore | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007080 | Mitotic metaphase plate congression | IMP | biological_process |
| GO:0031577 | Spindle checkpoint | IEA | biological_process |
| GO:0034501 | Protein localization to kinetochore | IMP | biological_process |
| GO:0043515 | Kinetochore binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9508731279 | 0.0000736142 | 0.9999902473 | 0.0145684211 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4959416996 |
| GSE13712_SHEAR | Down | -0.0867580452 |
| GSE13712_STATIC | Down | -0.0490784215 |
| GSE19018 | Down | -3.1476820100 |
| GSE19899_A1 | Down | -0.8214048091 |
| GSE19899_A2 | Down | -2.6553210599 |
| PubMed_21979375_A1 | Down | -1.5605432231 |
| PubMed_21979375_A2 | Down | -2.3909430746 |
| GSE35957 | Down | -0.9229495046 |
| GSE36640 | Down | -1.2618944979 |
| GSE54402 | Up | 0.5980450782 |
| GSE9593 | Down | -1.1974422921 |
| GSE43922 | Down | -1.0005370649 |
| GSE24585 | Up | 0.0452463619 |
| GSE37065 | Down | -0.1665480548 |
| GSE28863_A1 | Down | -0.8046527221 |
| GSE28863_A2 | Up | 0.7922784105 |
| GSE28863_A3 | Down | -0.8896289349 |
| GSE28863_A4 | Down | -0.0977100287 |
| GSE48662 | Down | -1.1698518445 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT004899 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004899 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
