HCSGD entry for NSUN2
1. General information
| Official gene symbol | NSUN2 |
|---|---|
| Entrez ID | 54888 |
| Gene full name | NOP2/Sun RNA methyltransferase family, member 2 |
| Other gene symbols | MISU MRT5 SAKI TRM4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0016428 | TRNA (cytosine-5-)-methyltransferase activity | IDA | molecular_function |
| GO:0030488 | TRNA methylation | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0539055583 | 0.7596780214 | 0.5060086305 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2088432670 |
| GSE13712_SHEAR | Up | 0.2229512292 |
| GSE13712_STATIC | Up | 0.1295359174 |
| GSE19018 | Down | -0.6992333154 |
| GSE19899_A1 | Up | 0.4474088841 |
| GSE19899_A2 | Up | 0.8337390042 |
| PubMed_21979375_A1 | Up | 0.2729819137 |
| PubMed_21979375_A2 | Up | 0.7533781331 |
| GSE35957 | Down | -0.1674946928 |
| GSE36640 | Down | -0.1538725334 |
| GSE54402 | Up | 0.5592059138 |
| GSE9593 | Down | -0.3914545243 |
| GSE43922 | Up | 0.3483038574 |
| GSE24585 | Down | -0.1576647061 |
| GSE37065 | Up | 0.0641349469 |
| GSE28863_A1 | Up | 0.1942659096 |
| GSE28863_A2 | Up | 0.5518090178 |
| GSE28863_A3 | Up | 0.0089948969 |
| GSE28863_A4 | Down | -0.0623865881 |
| GSE48662 | Down | -0.3902885203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022997 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041441 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045478 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051217 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052294 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052738 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26992231 | RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence |
| 26992231 | However, whether NSUN2 influences premature cellular senescence remains untested |
| 26992231 | Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC |
Entries Per Page
Displaying Page of
