HCSGD entry for PCSK4
1. General information
| Official gene symbol | PCSK4 |
|---|---|
| Entrez ID | 54760 |
| Gene full name | proprotein convertase subtilisin/kexin type 4 |
| Other gene symbols | PC4 SPC5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002080 | Acrosomal membrane | IEA | cellular_component |
| GO:0004252 | Serine-type endopeptidase activity | IBA IEA | molecular_function |
| GO:0006508 | Proteolysis | IBA IEA | biological_process |
| GO:0007339 | Binding of sperm to zona pellucida | IEA | biological_process |
| GO:0007340 | Acrosome reaction | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0048240 | Sperm capacitation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2981100870 | 0.8630426883 | 0.9969317206 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0865942987 |
| GSE13712_SHEAR | Down | -0.0282619695 |
| GSE13712_STATIC | Down | -0.3307796594 |
| GSE19018 | Up | 0.1427407804 |
| GSE19899_A1 | Down | -0.1233843206 |
| GSE19899_A2 | Up | 0.3003088884 |
| PubMed_21979375_A1 | Up | 0.0399338653 |
| PubMed_21979375_A2 | Down | -0.2746713225 |
| GSE35957 | Up | 0.1195126310 |
| GSE36640 | Up | 0.1171867580 |
| GSE54402 | Down | -0.0998678706 |
| GSE9593 | Up | 0.2736252405 |
| GSE43922 | Up | 0.1260323394 |
| GSE24585 | Up | 0.2120365169 |
| GSE37065 | Up | 0.0225867680 |
| GSE28863_A1 | Down | -0.0486318188 |
| GSE28863_A2 | Up | 0.0812374991 |
| GSE28863_A3 | Up | 0.5047912030 |
| GSE28863_A4 | Up | 0.1534841322 |
| GSE48662 | Up | 0.1369034195 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018385 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
