HCSGD entry for MARCH5
1. General information
| Official gene symbol | MARCH5 |
|---|---|
| Entrez ID | 54708 |
| Gene full name | membrane-associated ring finger (C3HC4) 5 |
| Other gene symbols | MARCH-V MITOL RNF153 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0051020 | GTPase binding | IPI | molecular_function |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
| GO:0070585 | Protein localization to mitochondrion | IMP | biological_process |
| GO:0090140 | Regulation of mitochondrial fission | IMP | biological_process |
| GO:0090141 | Positive regulation of mitochondrial fission | IMP | biological_process |
| GO:0090344 | Negative regulation of cell aging | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1152103454 | 0.9482013715 | 0.6971152874 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1719089584 |
| GSE13712_SHEAR | Up | 0.2176567461 |
| GSE13712_STATIC | Up | 0.3364144402 |
| GSE19018 | Down | -0.1507384399 |
| GSE19899_A1 | Up | 0.2942180257 |
| GSE19899_A2 | Up | 0.4759713336 |
| PubMed_21979375_A1 | Up | 0.7185119279 |
| PubMed_21979375_A2 | Up | 0.1739382163 |
| GSE35957 | Down | -0.0444534006 |
| GSE36640 | Up | 0.0340704563 |
| GSE54402 | Up | 0.2215629694 |
| GSE9593 | Down | -0.0081259328 |
| GSE43922 | Up | 0.0753782749 |
| GSE24585 | Down | -0.0950934816 |
| GSE37065 | Up | 0.0645411946 |
| GSE28863_A1 | Up | 0.1104994020 |
| GSE28863_A2 | Up | 0.0959067682 |
| GSE28863_A3 | Up | 0.0070332407 |
| GSE28863_A4 | Up | 0.2108761598 |
| GSE48662 | Down | -0.5812956758 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028466 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051528 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20103533 | Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 |
| 20103533 | Here, we show that shRNA-mediated MARCH5 knockdown promoted the accumulation of highly interconnected and elongated mitochondria |
| 20103533 | Cells transfected with MARCH5 shRNA or a MARCH5 RING domain mutant displayed cellular enlargement and flattening accompanied by increased senescence-associated beta-galactosidase (SA-beta-Gal) activity, indicating that these cells had undergone cellular senescence |
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